SIRT7: Sirtuin 7 – A Key Regulator of Ribosomal RNA Transcription and Cellular Homeostasis
Comprehensive genomic and functional overview of SIRT7, a NAD+-dependent deacetylase involved in chromatin regulation, metabolism, and aging.
Gene Information Card
| Symbol | SIRT7 |
|---|---|
| Full Name | Sirtuin 7 |
| Gene Type | Protein-coding |
| Chromosomal Location | 17q25.3 |
| NCBI Gene ID | 51547 ncbi.nlm.nih.gov/gene/51547 |
| Ensembl ID | ENSG00000187531 |
| UniProt ID | Q9NRC8 |
| OMIM ID | 606212 |
| HGNC ID | 14936 |
| Aliases | SIR2L7, SIR2-like protein 7 |
Description
SIRT7 is a member of the sirtuin family of NAD+-dependent deacetylases. It localizes to the nucleolus and acts as a positive regulator of RNA polymerase I transcription by deacetylating histones (e.g., H3K18ac) and transcription factors. SIRT7 also modulates chromatin compaction, DNA repair, metabolism, and stress responses. Its dysregulation is linked to aging, metabolic disorders, and multiple cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | SIRT7 overexpression promotes cell proliferation and tumor growth by deacetylating H3K18ac at rDNA promoters, enhancing rRNA synthesis. | PMID: 23376921 |
| Metabolic syndrome | SIRT7 deficiency impairs mitochondrial function and insulin sensitivity, leading to hepatic steatosis and glucose intolerance. | PMID: 24623306 |
| Aging and longevity | SIRT7 loss accelerates cellular senescence and shortens lifespan in mice, partly through p53 hyperacetylation and mitochondrial dysfunction. | PMID: 24623306 |
| Breast cancer | SIRT7 upregulation correlates with poor prognosis; it deacetylates H3K18ac to repress tumor suppressor genes. | PMID: 25921531 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 8.2 | Medium |
| Heart | 6.5 | Medium |
| Skeletal muscle | 5.1 | Low |
| Kidney | 4.3 | Low |
| Brain | 3.0 | Low |
| Testis | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 (liver cancer) | 7.8 | High expression |
| MCF7 (breast cancer) | 6.2 | Moderate expression |
| HEK293 (embryonic kidney) | 4.5 | Low expression |
| K562 (leukemia) | 3.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337C>T (p.Arg113Trp) | Missense | <0.01% | Unknown functional impact; rare population variant |
| c.458G>A (p.Arg153Gln) | Missense | <0.01% | Reported in COSMIC; potential loss-of-function |
| c.622C>T (p.Arg208Cys) | Missense | <0.01% | Found in cancer samples; effect unclear |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants (e.g., p.Arg153Gln) may reduce deacetylase activity, impairing rRNA transcription and mitochondrial homeostasis.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported in SIRT7.
Dominant Negative (DN)
No dominant-negative mutations described for SIRT7.
View complete mutation data：
Gene Ontology (GO)
| • NAD-dependent histone deacetylase activity (H3K18 specific) | • Chromatin silencing at rDNA |
| • Positive regulation of RNA polymerase I transcription | • Nucleolus localization |
| • Protein deacetylation | • Cellular response to stress |
Pathways
• rRNA transcription by RNA polymerase I
• NAD+ metabolism
• p53 signaling pathway
• Mitochondrial biogenesis
Protein Summary
SIRT7 is a 400-amino-acid NAD+-dependent deacetylase predominantly localized in the nucleolus. It specifically deacetylates histone H3 lysine 18 (H3K18ac) and non-histone targets such as p53 and GABPβ1. By promoting rRNA transcription and repressing tumor suppressor genes, SIRT7 regulates cell growth, metabolism, and genomic stability. Its expression is elevated in several cancers and reduced in metabolic tissues during aging.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SIRT7 Knockout HEK293 Cell Line | EDJ-KQ15266 | Human | 51547 | Details Get a Quote |
| SIRT7 Knockout A-549 Cell Line | EDJ-KQ18097 | Human | 51547 | Details Get a Quote |
| SIRT7 Knockout HeLa Cell Line | EDJ-KQ45956 | Human | 51547 | Details Get a Quote |
| SIRT7 Knockout HCT 116 Cell Line | EDJ-KQ48142 | Human | 51547 | Details Get a Quote |
| SIRT7 Knockout HeLa S3 Cell Line | EDJ-KZ465 | Human | 51547 | Details Get a Quote |
| SIRT7 Knockout U-87MG ATCC Cell Line | EDJ-KZ466 | Human | 51547 | Details Get a Quote |
| SIRT7 Knockout HAP1 Cell Line | EDC08288 | Human | 51547 | Details Get a Quote |
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