SENP5
Sentrin/SUMO-specific protease 5
Gene Information Card
| Symbol | SENP5 |
|---|---|
| Full Name | Sentrin/SUMO-specific protease 5 |
| Gene Type | Protein coding |
| Chromosomal Location | 3q29 |
| NCBI Gene ID | 205564 ncbi.nlm.nih.gov/gene/205564 |
| Ensembl ID | ENSG00000164050 |
| UniProt ID | Q96HI0 |
| OMIM ID | 612845 |
| HGNC ID | 17802 |
| Aliases | SMT3IP2, SUMO-specific protease 5 |
Description
SENP5 encodes a member of the sentrin/SUMO-specific protease family. The encoded protein processes SUMO precursors and deconjugates SUMO from target proteins, playing a critical role in SUMOylation regulation, cell cycle progression, and mitochondrial dynamics.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of SENP5 alters SUMOylation of key oncoproteins and tumor suppressors, promoting cell proliferation and genomic instability. | PMID: 23431136, COSMIC |
| Orofacial clefts | SENP5 mutations may disrupt SUMOylation during craniofacial development. | OMIM: 612845 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 9.8 | Medium |
| Brain | 6.2 | Low |
| Liver | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.3 | High expression |
| HEK 293 | 11.2 | Moderate expression |
| MCF7 | 8.7 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1123C>T (p.Arg375Trp) | Missense | <0.01% | Unknown functional impact |
| c.1456G>A (p.Glu486Lys) | Missense | <0.01% | Potential loss of function |
Mutation functional classification
Loss of Function (LOF)
Missense mutations in the catalytic domain may impair protease activity.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• SUMOylation (Reactome: R-HSA-2990846)
• Cell Cycle
• Mitotic (Reactome: R-HSA-69278)
Protein Summary
SENP5 is a cysteine protease that removes SUMO (small ubiquitin-like modifier) from target proteins. It localizes to the nucleolus and mitochondria, regulating mitotic progression, ribosomal biogenesis, and mitochondrial fission. Its activity is essential for cell viability and is implicated in cancer development.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SENP5 Knockout HEK293 Cell Line | EDJ-KQ6185 | Human | 205564 | Details Get a Quote |
| SENP5 Knockout A-549 Cell Line | EDJ-KQ30016 | Human | 205564 | Details Get a Quote |
| SENP5 Knockout HCT 116 Cell Line | EDJ-KQ30017 | Human | 205564 | Details Get a Quote |
| SENP5 Knockout HeLa Cell Line | EDJ-KQ30018 | Human | 205564 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
