RNF185: Ring Finger Protein 185
E3 ubiquitin-protein ligase involved in ER-associated degradation and autophagy
Gene Information Card
| Symbol | RNF185 |
|---|---|
| Full Name | ring finger protein 185 |
| Gene Type | protein coding |
| Chromosomal Location | 22q12.3 |
| NCBI Gene ID | 91445 ncbi.nlm.nih.gov/gene/91445 |
| Ensembl ID | ENSG00000100280 |
| UniProt ID | Q96GF1 |
| OMIM ID | 614561 |
| HGNC ID | 26761 |
| Aliases | FLJ32709, MGC26594 |
Description
RNF185 (ring finger protein 185) encodes a RING finger domain-containing E3 ubiquitin-protein ligase. The protein localizes to the endoplasmic reticulum (ER) membrane and participates in ER-associated degradation (ERAD) and autophagy. It mediates ubiquitination of target proteins, influencing protein quality control and cellular stress responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease association reported in ClinVar | Not applicable | No pathogenic variants curated in ClinVar as of 2025 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Thyroid | 8.7 | Low |
| Adrenal gland | 7.9 | Low |
| Brain | 6.5 | Low |
| Liver | 5.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.1 | Embryonic kidney cells |
| HeLa | 8.4 | Cervical carcinoma cells |
| K562 | 6.7 | Leukemia cells |
| HepG2 | 5.9 | Hepatocellular carcinoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations in COSMIC | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • ubiquitin-protein transferase activity (GO:0004842) | • protein binding (GO:0005515) |
| • endoplasmic reticulum (GO:0005783) | • integral component of membrane (GO:0016021) |
| • ubiquitin protein ligase activity (GO:0061630) | • ubiquitin-dependent protein catabolic process (GO:0006511) |
Pathways
• Endoplasmic reticulum-associated degradation (ERAD) pathway
• Ubiquitin-proteasome pathway
Protein Summary
RNF185 is a 176-amino acid E3 ubiquitin-protein ligase with a RING-type zinc finger domain. It is anchored to the ER membrane and facilitates ubiquitination of misfolded proteins, targeting them for proteasomal degradation. It also plays a role in autophagy by modulating the ubiquitination of key autophagy regulators.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RNF185 Knockout HEK293 Cell Line | EDJ-KQ2949 | Human | 91445 | Details Get a Quote |
| RNF185 Knockout A-549 Cell Line | EDJ-KQ24080 | Human | 91445 | Details Get a Quote |
| RNF185 Knockout HCT 116 Cell Line | EDJ-KQ24081 | Human | 91445 | Details Get a Quote |
| RNF185 Knockout HeLa Cell Line | EDJ-KQ24082 | Human | 91445 | Details Get a Quote |
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