PPP5C Gene - Protein Phosphatase 5 Catalytic Subunit
A serine/threonine phosphatase involved in cellular signaling, stress response, and cancer.
Gene Information Card
| Symbol | PPP5C |
|---|---|
| Full Name | Protein Phosphatase 5 Catalytic Subunit |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.32 |
| NCBI Gene ID | 5536 ncbi.nlm.nih.gov/gene/5536 |
| Ensembl ID | ENSG00000104879 |
| UniProt ID | P53041 |
| OMIM ID | 600658 |
| HGNC ID | 9320 |
| Aliases | PP5, PPP5 |
Description
PPP5C encodes the catalytic subunit of protein phosphatase 5, a serine/threonine phosphatase that regulates diverse cellular processes including stress response, cell cycle, and signal transduction. It interacts with heat shock proteins and glucocorticoid receptors.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | PPP5C overexpression may promote tumor growth via dephosphorylation of key signaling proteins. | PMID: 23431137 |
| Prostate Cancer | PPP5C upregulation correlates with androgen receptor activity and poor prognosis. | PMID: 25620006 |
| Hepatocellular Carcinoma | PPP5C knockdown reduces cell proliferation and induces apoptosis. | PMID: 27562872 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 15.2 | Medium |
| Kidney | 10.1 | Medium |
| Testis | 18.7 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.5 | Cervical cancer cell line |
| HEK293 | 11.2 | Embryonic kidney cells |
| MCF7 | 16.8 | Breast cancer cell line |
| HepG2 | 13.9 | Liver cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown functional impact |
| c.487G>A (p.Glu163Lys) | Missense | <0.01% | Potential loss of phosphatase activity |
| c.1123A>G (p.Thr375Ala) | Missense | <0.01% | Reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
p.Glu163Lys may reduce catalytic activity.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein serine/threonine phosphatase activity | • signal transduction |
| • cell cycle | • response to stress |
| • protein dephosphorylation |
Pathways
• Glucocorticoid receptor signaling
• MAPK signaling
• HSP90 chaperone cycle
Protein Summary
PPP5C is a 58 kDa serine/threonine phosphatase with a tetratricopeptide repeat (TPR) domain at the N-terminus and a catalytic domain at the C-terminus. It is ubiquitously expressed and involved in dephosphorylation of multiple substrates including ASK1, p53, and glucocorticoid receptors.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PPP5C Knockout HEK293 Cell Line | EDJ-KQ737 | Human | 5536 | Details Get a Quote |
| PPP5C Knockout A-549 Cell Line | EDJ-KQ19371 | Human | 5536 | Details Get a Quote |
| PPP5C Knockout HCT 116 Cell Line | EDJ-KQ19372 | Human | 5536 | Details Get a Quote |
| PPP5C Knockout HeLa Cell Line | EDJ-KQ19373 | Human | 5536 | Details Get a Quote |
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