KDM4D
Lysine Demethylase 4D
Gene Information Card
| Symbol | KDM4D |
|---|---|
| Full Name | Lysine Demethylase 4D |
| Gene Type | Protein coding |
| Chromosomal Location | 11q21 |
| NCBI Gene ID | 55693 ncbi.nlm.nih.gov/gene/55693 |
| Ensembl ID | ENSG00000166166 |
| UniProt ID | Q6B0I6 |
| OMIM ID | 609765 |
| HGNC ID | HD: 29138 |
| Aliases | JMJD2D, JHDM3D, bA145I24.1 |
Description
KDM4D (lysine demethylase 4D) is a gene encoding a histone demethylase that specifically demethylates histone H3 lysine 9 (H3K9me3) and H3 lysine 36 (H3K36me3), playing a key role in epigenetic regulation, chromatin remodeling, and transcriptional activation. It is involved in cell cycle progression, DNA damage response, and is implicated in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Overexpression promotes androgen receptor signaling and cell proliferation | PMID: 21947068 |
| Breast cancer | Upregulation correlates with poor prognosis and increased metastasis | PMID: 25944712 |
| Colorectal cancer | KDM4D overexpression enhances tumor growth via H3K9me3 demethylation | PMID: 27323850 |
| Gastric cancer | Elevated expression linked to tumor invasion and EMT | PMID: 28692040 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 8.2 | Medium |
| Bone marrow | 6.5 | Medium |
| Lymph node | 5.1 | Low |
| Brain | 2.3 | Low |
| Liver | 1.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 7.4 | Cervical cancer cell line |
| MCF7 | 6.9 | Breast cancer cell line |
| LNCaP | 8.1 | Prostate cancer cell line |
| HCT116 | 7.8 | Colorectal cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1072C>T (p.Arg358Trp) | Missense | <0.1% | Unknown functional effect |
| c.1465G>A (p.Glu489Lys) | Missense | <0.1% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in KDM4D.
Gain of Function (GOF)
Overexpression in multiple cancers suggests potential gain-of-function role.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • Histone H3-K9 demethylation | • Histone H3-K36 demethylation |
| • Chromatin remodeling | • Transcription coactivator activity |
| • Zinc ion binding |
Pathways
• Epigenetic regulation of gene expression
• Chromatin organization
• DNA damage response
Protein Summary
KDM4D is a JmjC-domain-containing histone demethylase that removes methyl groups from H3K9me3 and H3K36me3, thereby activating transcription. It is involved in androgen receptor signaling, cell proliferation, and is overexpressed in several cancers, making it a potential therapeutic target.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KDM4D Knockout HEK293 Cell Line | EDJ-KQ1044 | Human | 55693 | Details Get a Quote |
| KDM4D Knockout HCT 116 Cell Line | EDJ-KQ18809 | Human | 55693 | Details Get a Quote |
| KDM4D Knockout HeLa Cell Line | EDJ-KQ56616 | Human | 55693 | Details Get a Quote |
| KDM4D Knockout A-549 Cell Line | EDJ-KQ65115 | Human | 55693 | Details Get a Quote |
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