HDAC11: Histone Deacetylase 11
A key epigenetic regulator with roles in immune modulation and cancer
Gene Information Card
| Symbol | HDAC11 |
|---|---|
| Full Name | Histone Deacetylase 11 |
| Gene Type | Protein coding |
| Chromosomal Location | 3p25.1 |
| NCBI Gene ID | 79885 ncbi.nlm.nih.gov/gene/79885 |
| Ensembl ID | ENSG00000163528 |
| UniProt ID | Q96DB2 |
| OMIM ID | 607226 |
| HGNC ID | 19086 |
| Aliases | HD11, HDAC11 |
Description
HDAC11 (Histone Deacetylase 11) is a protein-coding gene that encodes a class IV histone deacetylase. It catalyzes the removal of acetyl groups from lysine residues of histone and non-histone proteins, playing a critical role in transcriptional regulation, cell cycle progression, and immune function. HDAC11 is the smallest member of the HDAC family and is predominantly localized in the nucleus.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of HDAC11 expression alters gene expression profiles promoting oncogenesis | COSMIC, ClinVar |
| Immune disorders | HDAC11 modulates cytokine expression and T-cell differentiation | NCBI Gene, UniProt |
| Neurodevelopmental disorders | Potential role via histone deacetylation affecting neuronal gene expression | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Low |
| Kidney | 8.1 | Medium |
| Liver | 3.4 | Low |
| Testis | 12.7 | Medium |
| Spleen | 6.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.3 | Embryonic kidney cells |
| K562 | 7.8 | Leukemia cells |
| HeLa | 9.1 | Cervical cancer cells |
| HepG2 | 4.5 | Liver cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | Rare | Unknown functional impact |
| c.374C>T | Nonsense | Rare | Predicted loss of function |
| c.689G>A | Missense | Rare | Alters catalytic activity |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations that truncate the protein or disrupt the catalytic domain are predicted to cause loss of deacetylase activity.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported in HDAC11.
Dominant Negative (DN)
No dominant-negative mutations have been described for HDAC11.
View complete mutation data：
Gene Ontology (GO)
| • histone deacetylase activity (GO:0004407) | • nucleus (GO:0005634) |
| • regulation of transcription (GO:0006355) | • histone deacetylation (GO:0016575) |
| • positive regulation of transcription by RNA polymerase II (GO:0045944) |
Pathways
• Epigenetic regulation of gene expression
• Notch signaling pathway
• IL-4 signaling pathway
Protein Summary
HDAC11 is a 347-amino acid class IV histone deacetylase that removes acetyl groups from histones H3 and H4, as well as non-histone substrates. It is involved in transcriptional repression, immune response modulation, and cell cycle control. HDAC11 is highly expressed in testis and kidney, and its dysregulation is linked to cancer and immune disorders.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HDAC11 Knockout HEK293 Cell Line | EDJ-KQ13729 | Human | 79885 | Details Get a Quote |
| HDAC11 Knockout HCT 116 Cell Line | EDJ-KQ42225 | Human | 79885 | Details Get a Quote |
| HDAC11 Knockout A-549 Cell Line | EDJ-KQ43486 | Human | 79885 | Details Get a Quote |
| HDAC11 Knockout HeLa Cell Line | EDJ-KQ43488 | Human | 79885 | Details Get a Quote |
| HDAC11 Knockout HAP1 Cell Line | EDC09216 | Human | 79885 | Details Get a Quote |
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