FOSL1 (FOS Like 1, AP-1 Transcription Factor Subunit)
A key AP-1 transcription factor involved in cell proliferation, differentiation, and transformation; implicated in cancer and inflammatory diseases.
Gene Information Card
| Symbol | FOSL1 |
|---|---|
| Full Name | FOS Like 1, AP-1 Transcription Factor Subunit |
| Gene Type | Protein-coding |
| Chromosomal Location | 11q13.1 |
| NCBI Gene ID | 8061 ncbi.nlm.nih.gov/gene/8061 |
| Ensembl ID | ENSG00000175592 |
| UniProt ID | P15407 |
| OMIM ID | 136535 |
| HGNC ID | 4007 |
| Aliases | FRA-1, fra-1, FRA1 |
Description
FOSL1 (FOS Like 1, AP-1 Transcription Factor Subunit) encodes a leucine zipper protein that dimerizes with JUN proteins to form the AP-1 transcription factor complex. FOSL1 regulates gene expression in response to growth factors, cytokines, and stress signals, playing critical roles in cell proliferation, differentiation, apoptosis, and transformation. Overexpression of FOSL1 is frequently observed in various cancers and is associated with aggressive tumor phenotypes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | FOSL1 overexpression promotes invasion and metastasis via AP-1 target genes (e.g., MMPs, uPA) | PMID: 21502514; COSMIC |
| Lung Cancer | FOSL1 amplification and overexpression drive cell proliferation and resistance to EGFR inhibitors | PMID: 26921328; COSMIC |
| Colorectal Cancer | FOSL1 upregulation correlates with poor prognosis and activates Wnt/β-catenin signaling | PMID: 25695633; COSMIC |
| Osteosarcoma | FOSL1 is a direct target of FOS and contributes to tumorigenesis | PMID: 15988017; COSMIC |
| Inflammatory Diseases | FOSL1 modulates cytokine production in macrophages and is linked to rheumatoid arthritis | PMID: 20037588 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Breast | 8.3 | Medium |
| Colon | 6.7 | Low |
| Bone Marrow | 2.1 | Low |
| Placenta | 15.2 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (Lung Cancer) | 18.4 | High expression |
| MCF7 (Breast Cancer) | 9.8 | Medium expression |
| HCT116 (Colorectal Cancer) | 11.2 | Medium expression |
| HEK293 (Embryonic Kidney) | 5.6 | Low expression |
| U2OS (Osteosarcoma) | 14.1 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.1% (COSMIC) | Likely loss of start codon; functional impact unknown |
| c.214C>T (p.Arg72Trp) | Missense | <0.1% (COSMIC) | Rare; no known disease association |
| c.487G>A (p.Gly163Arg) | Missense | <0.1% (COSMIC) | Rare; no known disease association |
| Amplification | Copy number gain | ~5% in lung cancer (COSMIC) | Associated with overexpression and poor prognosis |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in human disease; experimental knockout in mice shows reduced cell proliferation.
Gain of Function (GOF)
Gene amplification and overexpression in multiple cancers act as gain-of-function, enhancing AP-1 transcriptional activity and promoting oncogenic phenotypes.
Dominant Negative (DN)
No dominant-negative mutations described in FOSL1; dominant-negative effects are typically mediated by truncated FOS family members.
View complete mutation data：
Gene Ontology (GO)
Pathways
• AP-1 transcription factor network
• MAPK signaling pathway (Reactome: R-HSA-5673001)
• TNF signaling pathway (KEGG: hsa04668)
• IL-17 signaling pathway (KEGG: hsa04657)
• Osteoclast differentiation (KEGG: hsa04380)
Protein Summary
FOSL1 (FRA-1) is a 271-amino acid protein (UniProt P15407) belonging to the FOS family of basic leucine zipper (bZIP) transcription factors. It forms heterodimers with JUN proteins to bind AP-1 sites in DNA. FOSL1 lacks a transactivation domain present in other FOS members, making it a weaker transcriptional activator. It is rapidly induced by growth factors and stress signals and is stabilized by phosphorylation. FOSL1 is overexpressed in many cancers and contributes to invasion, metastasis, and drug resistance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| FOSL1 Knockout HEK293 Cell Line | EDJ-KQ298 | Human | 8061 | Details Get a Quote |
| FOSL1 Knockout A-549 Cell Line | EDJ-KQ18416 | Human | 8061 | Details Get a Quote |
| FOSL1 Knockout HCT 116 Cell Line | EDJ-KQ18417 | Human | 8061 | Details Get a Quote |
| FOSL1 Knockout HeLa Cell Line | EDJ-KQ18418 | Human | 8061 | Details Get a Quote |
