RNF213 Knockout HeLa Cell Line

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RNF213 Knockout HeLa Cell Line
Cat.No.:

EDJ-KQ22193

Species:

Human

Cell Name:

HeLa

Gene:

RNF213

Gene ID:

57674

Size:

1×10⁶cells

RNF213 Knockout Cell Line (Hela) is an exclusive upgraded CRISPR/Cas9 system-mediated gene knockout cell, with the advantages of Optimized Strategy Design, Efficient Cell Transfection, High-Performance Cas9 Protein and Hassle-Free Cell Selection.
Cat.No. EDJ-KQ22193
Product Name RNF213 Knockout Hela Cell Line
Cell Line Hela
Cellosaurus ID CVCL_0030
Cell Line Synonyms HELA, Hela, He La, He-La, HeLa-CCL2, Henrietta Lacks cells, Helacyton gartleri
Gene
NCBI Gene ID
Gene Synonyms ALO17|C17orf27|KIAA1618|MYMY2|MYSTR|NET57
Summary
This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Associated Diseases Cervical Carcinoma
Morphology Adherent
Passage Ratio 1/5, 2days
Complete Culture Medium MEM + 10% FBS
Freezing Medium 70%Complete culture medium+ 20% FBS+ 10% DMSO
QC Indels validated by Sanger sequencing; sterility confirmed via microbial testing.
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
LociSTR Info (Sample Cell)
Sample Cell Line: HeLa		STR Info (Cell bank)
Cell Line: HeLa
Allele1Allele2Allele1Allele2
Amelogenin X X
CSF1PO 9 10 9 10
D1S1656 12 15 12 15
D2S1338 17 17
D3S1358 15 18 15 18
D5S818 11 12 11 12
D6S1043 18 18
D7S820 8 12 8 12
D8S1179 12 13 12 13
D12S391 20 25 20 25
D13S317 12 14 12 14
D16S539 9 10 9 10
D18S51 16 16
D19S433 13 14 13 14
D21S11 27 28 27 28
FGA 18 21 18 21
Penta D 8 15 8 15
Penta E 7 17 7 17
TPOX 8 12 8 12
VWA 16 18 16 18
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.

Research Publications

IF=2.2
Biochemical and biophysical research communications
IF=1.3
Genes to cells : devoted to molecular & cellular mechanisms
This KO model may be useful for: - Investigating the role of RNF213 in EGFR and HER2 signaling pathway regulation in cancer cells - Studying downstream signaling mechanisms and target identification in oncogenic pathways - Exploring the link between RNF213 and endoplasmic reticulum (ER) stress responses via SEL1L modulation - Functional validation of RNF213 as a susceptibility gene for moyamoya disease - Drug screening and therapeutic target assessment for RNF213-associated cancers and vascular disorders

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HeLaHeLa

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