FADD Knockout 32D Cell Line
Cat.No.:
EDJ-KZ231
Species:
Mouse
Cell Name:
32D
Gene:
FADD
Gene ID:
8772
Size:
1×10⁶cells
| Cat.No. | EDJ-KZ231 |
|---|---|
| Product Name | FADD Knockout 32D Cell Line |
| Species | Mouse |
| Cell Line | 32D |
| Cellosaurus ID | CVCL_0118 |
| Gene | FADD |
| Gene Synonyms | GIG3|IMD90|MORT1 |
| Summary |
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
|
| QC | Indels validated by Sanger sequencing; sterility confirmed via microbial testing. |
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
Required Accessories
Required Companion Kits
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