MLH1 Knockout AGS Cell Line
Cat.No.:
EDJ-KZ352
Species:
Human
Cell Name:
AGS
Gene:
MLH1
Gene ID:
4292
Size:
1×10⁶cells
| Cat.No. | EDJ-KZ352 |
|---|---|
| Product Name | MLH1 Knockout AGS Cell Line |
| Cell Line | AGS |
| Cellosaurus ID | CVCL_0139 |
| Gene | MLH1 |
| Gene Synonyms | COCA2|FCC2|HNPCC|HNPCC2|LYNCH2|MLH-1|MMRCS1|hMLH1 |
| Summary |
The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]
|
| Associated Diseases | Gastric Carcinoma |
| QC | Indels validated by Sanger sequencing; sterility confirmed via microbial testing. |
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
| Loci | STR Info (Sample Cell) Sample Cell Line: AGS | STR Info (Cell bank) Cell Line: AGS | ||
| Allele1 | Allele2 | Allele1 | Allele2 | |
| Amelogenin | X | X | ||
| D1S1656 | 14 | 16 | 14 | 16 |
| D2S1338 | 20 | 22 | 20 | 22 |
| D3S1358 | 16 | 16 | ||
| D5S818 | 9 | 12 | 9 | 12 |
| D7S820 | 10 | 11 | 10 | 11 |
| D8S1179 | 13 | 13 | ||
| D12S391 | 19 | 20 | 19 | 20 |
| D13S317 | 12 | 12 | ||
| D16S539 | 11 | 13 | 11 | 13 |
| D18S51 | 13 | 13 | ||
| D19S433 | 13.2 | 16 | 13.2 | 16 |
| D21S11 | 29 | 29 | ||
| FGA | 23 | 24 | 23 | 24 |
| Penta D | 9 | 10 | 9 | 10 |
| Penta E | 13 | 16 | 13 | 16 |
| TH01 | 6 | 7 | 6 | 7 |
| TPOX | 11 | 12 | 11 | 12 |
| VWA | 16 | 17 | 16 | 17 |
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
Required Accessories
Cell Culture Optimization Series
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