IL10 Knockdown RAW 264.7 stable cell line
Cat.No.:
EDC07021
Species:
Mouse
Gene:
IL10
Cell Name:
RAW 264.7
EDITGENE provides IL10 Knockdown RAW 264.7 stable cell line generated using a well-established RNA interference-based stable transfection method. The cell line has undergone rigorous quality control, including STR authentication and mycoplasma testing, ensuring a stable and reliable model suitable for long-term culture.
| Cat.No. | EDC07021 |
|---|---|
| Product Name | IL10 Knockdown RAW 264.7 stable cell line |
| Cell line | RAW 264.7 |
| Gene ID | |
| Cellosaurus ID | CVCL_0493 |
| Cell Line Synonyms | RAW264, RAW2647, RAW264.7, RAW-264.7, Raw 264.7, Raw264.7 |
| Gene | IL10 |
| Gene Synonyms | CSIF|GVHDS|IL-10|IL10A|TGIF |
| Summary |
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]
|
| Associated Diseases | Leukemia |
| Morphology | Adherent |
| Passage Ratio | 1:5,Pipette gently up and down |
| Complete Culture Medium | DMEM+10% FBS |
| Freezing Medium | 70% complete culture medium+20% FBS+10% DMSO；95% complete culture medium+5% DMSO |
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
| Loci | STR Info (Sample Cell) Sample Cell Line: RAW 264.7 | STR Info (Cell bank) Cell Line: RAW 264.7 | ||
| Allele1 | Allele2 | Allele1 | Allele2 | |
| 1-1 | 16 | 15 | 16 | |
| 1-2 | 17 | 17 | ||
| 2-1 | 16 | 16 | ||
| 3-2 | 14 | 14 | ||
| 4-2 | 22.3 | 22.3 | ||
| 5-5 | 14 | 15 | 14 | |
| 6-4 | 17 | 18 | 18 | |
| 6-7 | 12 | 13 | 12 | |
| 7-1 | 25.2 | 25.2 | ||
| 8-1 | 13 | 13 | ||
| 11-2 | 17 | 17 | ||
| 12-1 | 16 | 16 | ||
| 13-1 | 16.2 | 16.2 | ||
| 15-3 | 22.3 | 22.3 | ||
| 17-2 | 14 | 16 | 14 | 16 |
| 18-3 | 18 | 18 | ||
| 19-2 | 14 | 14 | ||
| X-1 | 24 | 24 | ||
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
