CEBPA Knockout HEK293 Cell Line

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CEBPA Knockout HEK293 Cell Line
Cat.No.:

EDJ-KQ50184

Species:

Human

Cell Name:

HEK293

Gene:

CEBPA

Gene ID:

1050

Size:

1×10⁶ cells

CEBPA Knockout Cell Line (HEK293) is an exclusive upgraded CRISPR/Cas9 system-mediated gene knockout cell, with the advantages of Optimized Strategy Design, Efficient Cell Transfection, High-Performance Cas9 Protein and Hassle-Free Cell Selection.
Cat.No. EDJ-KQ50184
Product Name CEBPA Knockout HEK293 Cell Line
Cell Line HEK293
Cellosaurus ID CVCL_0045
Cell Line Synonyms Hek293, HEK-293, HEK/293, (HEK)293, HEK 293, HEK,293, 293, 293 HEK, 293 Ad5, Graham 293, Graham-293, Human Embryonic Kidney 293
Gene CEBPA
NCBI Gene ID
Gene Synonyms C/EBP-alpha|CEBP
Summary
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
Associated Diseases Non-tumor
Morphology Adherent
Passage Ratio 1/2~1/4
Complete Culture Medium DMEM + 10% FBS
Freezing Medium 95% Complete Culture Medium+ 5% DMSO
QC Indels validated by Sanger sequencing; sterility confirmed via microbial testing.
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
LociSTR Info (Sample Cell)
Sample Cell Line: HEK293		STR Info (Cell bank)
Cell Line: HEK293
Allele1Allele2Allele1Allele2
Amelogenin X X
CSF1P0 12 11 12
D2S1338 19 19
D3S1358 15 17 15 17
D5S818 8 8 9
D7S820 11 12 11 12
D8S1179 12 14 12 14
D13S317 12 14 12 14
D16S539 9 13 9 13
D18S51 17 18 17 18
D19S433 15 18 15 18
D21S11 28 30.2 28 30.2
FGA 23 23
Penta D 9 10 9 10
Penta E 7 15 7 15
TH01 7 9.3 7 9.3
TPOX 11 11
vWA 16 19 16 19
D6S1043 11 11
D12S391 19 21 11 15
D2S441 11 15 11 15
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.

Related Publications

IF=10.6
The Journal of experimental medicine
This KO model may be useful for: - Investigating the role of CEBPA in hematopoietic progenitor cell fate decisions under chronic inflammatory stress. - Modeling clonal selection dynamics driven by interleukin-1 (IL-1) exposure in myeloid malignancies. - Studying the molecular mechanisms of CEBPA loss-of-function in leukemia initiation and progression. - Screening for therapeutic agents targeting CEBPA-deficient hematopoietic cells. - Exploring the interplay between chronic inflammation and transcriptional regulation in stem cell biology.

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