IL4I1
Interleukin 4 Induced 1
Gene Information Card
| Symbol | IL4I1 |
|---|---|
| Full Name | Interleukin 4 Induced 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.33 |
| NCBI Gene ID | 11107 ncbi.nlm.nih.gov/gene/11107 |
| Ensembl ID | ENSG00000104951 |
| UniProt ID | Q96RQ9 |
| OMIM ID | 609742 |
| HGNC ID | 5990 |
| Aliases | FIG1, LAAO, hLAAO |
Description
IL4I1 (Interleukin 4 Induced 1) encodes an L-amino acid oxidase that is induced by interleukin-4. The enzyme catalyzes the oxidative deamination of aromatic amino acids, producing hydrogen peroxide and ammonia. It plays a role in immune regulation, particularly in T-cell responses and antigen presentation. IL4I1 is expressed in immune cells and certain tumors, where it may contribute to immune evasion.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | IL4I1 expression in tumor microenvironment suppresses T-cell activity via H2O2 production | COSMIC, NCBI |
| Autoimmune diseases | Dysregulated IL4I1 may alter immune tolerance | UniProt, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Bone marrow | 8.1 | Low |
| Lung | 3.4 | Low |
| Small intestine | 2.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 | 15.3 | Monocytic cell line |
| Jurkat | 9.8 | T-cell line |
| HeLa | 2.5 | Cervical cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.857C>T | missense | <0.1% | p.Thr286Met; unknown functional impact |
| c.1123G>A | missense | <0.1% | p.Gly375Ser; unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • L-amino acid oxidase activity | • hydrogen peroxide biosynthetic process |
| • immune response | • oxidation-reduction process |
| • extracellular space |
Pathways
• Tryptophan metabolism
• Immune system
Protein Summary
IL4I1 is a secreted L-amino acid oxidase that converts aromatic amino acids (e.g., phenylalanine, tryptophan) into corresponding keto acids, ammonia, and hydrogen peroxide. The hydrogen peroxide produced can inhibit T-cell proliferation and modulate immune responses. The protein is implicated in immune tolerance and tumor immune evasion.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IL4I1 Knockout HEK293 Cell Line | EDJ-KQ3808 | Human | 259307 | Details Get a Quote |
| IL4I1 Knockout MDA-MB-231 Cell Line | EDJ-KZ299 | Human | 259307 | Details Get a Quote |
| IL4I1 Knockout HeLa Cell Line | EDJ-KQ59345 | Human | 259307 | Details Get a Quote |
| IL4I1 Knockout A-549 Cell Line | EDJ-KQ67808 | Human | 259307 | Details Get a Quote |
| IL4I1 Knockout HCT 116 Cell Line | EDJ-KQ76194 | Human | 259307 | Details Get a Quote |
| Il4i1 Knockout MC-38 Cell Line | EDC07568 | Mouse | 14204 | Details Get a Quote |
| IL4I1 Knockout THP-1 Cell Line | EDC07633 | Human | 259307 | Details Get a Quote |
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