SOD3 Knockout HeLa Cell Line

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SOD3 Knockout HeLa Cell Line
Cat.No.:

EDJ-KQ54534

Species:

Human

Cell Name:

HeLa

Gene:

SOD3

Gene ID:

6649

Size:

1×10⁶ cells

SOD3 Knockout Cell Line (Hela) is an exclusive upgraded CRISPR/Cas9 system-mediated gene knockout cell, with the advantages of Optimized Strategy Design, Efficient Cell Transfection, High-Performance Cas9 Protein and Hassle-Free Cell Selection.
Cat.No. EDJ-KQ54534
Product Name SOD3 Knockout Hela Cell Line
Cell Line Hela
Cellosaurus ID CVCL_0030
Cell Line Synonyms HELA, Hela, He La, He-La, HeLa-CCL2, Henrietta Lacks cells, Helacyton gartleri
Gene
NCBI Gene ID
Gene Synonyms EC-SOD
Summary
This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]
Associated Diseases Cervical Carcinoma
Morphology Adherent
Passage Ratio 1/5, 2days
Complete Culture Medium MEM + 10% FBS
Freezing Medium 70% Complete culture medium+ 20% FBS+ 10% DMSO
QC Indels validated by Sanger sequencing; sterility confirmed via microbial testing.
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
LociSTR Info (Sample Cell)
Sample Cell Line: HeLa		STR Info (Cell bank)
Cell Line: HeLa
Allele1Allele2Allele1Allele2
Amelogenin X X
CSF1PO 9 10 9 10
D1S1656 12 15 12 15
D2S1338 17 17
D3S1358 15 18 15 18
D5S818 11 12 11 12
D6S1043 18 18
D7S820 8 12 8 12
D8S1179 12 13 12 13
D12S391 20 25 20 25
D13S317 12 14 12 14
D16S539 9 10 9 10
D18S51 16 16
D19S433 13 14 13 14
D21S11 27 28 27 28
FGA 18 21 18 21
Penta D 8 15 8 15
Penta E 7 17 7 17
TPOX 8 12 8 12
VWA 16 18 16 18
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.

Research Publications

IF=4.9
International journal of molecular sciences
This KO model may be useful for: - Investigating the role of SOD3 in oxidative stress regulation and mitochondrial redox balance. - Studying the interplay between SOD3 and adenylate kinase isozyme 3 in mitochondrial energy metabolism. - Exploring metabolic reprogramming mechanisms in cancer cells, particularly in HeLa models. - Functional validation of SOD3 in cellular pathways linked to reactive oxygen species (ROS) signaling. - Supporting drug screening assays targeting oxidative stress-related metabolic vulnerabilities.

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