SEC31A Knockout HeLa Cell Line

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SEC31A Knockout HeLa Cell Line
Cat.No.:

EDJ-KQ33101

Species:

Human

Cell Name:

HeLa

Gene:

SEC31A

Gene ID:

22872

Size:

1×10⁶cells

SEC31A Knockout Cell Line (Hela) is an exclusive upgraded CRISPR/Cas9 system-mediated gene knockout cell, with the advantages of Optimized Strategy Design, Efficient Cell Transfection, High-Performance Cas9 Protein and Hassle-Free Cell Selection.
Cat.No. EDJ-KQ33101
Product Name SEC31A Knockout Hela Cell Line
Cell Line Hela
Cellosaurus ID CVCL_0030
Cell Line Synonyms HELA, Hela, He La, He-La, HeLa-CCL2, Henrietta Lacks cells, Helacyton gartleri
Gene
NCBI Gene ID
Gene Synonyms ABP125|ABP130|HPBKS|HSPC275|HSPC334|NEDSOSB|SEC31L1
Summary
The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Associated Diseases Cervical Carcinoma
Morphology Adherent
Passage Ratio 1/5, 2days
Complete Culture Medium MEM + 10% FBS
Freezing Medium 70%Complete culture medium+ 20% FBS+ 10% DMSO
QC Indels validated by Sanger sequencing; sterility confirmed via microbial testing.
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
LociSTR Info (Sample Cell)
Sample Cell Line: HeLa		STR Info (Cell bank)
Cell Line: HeLa
Allele1Allele2Allele1Allele2
Amelogenin X X
CSF1PO 9 10 9 10
D1S1656 12 15 12 15
D2S1338 17 17
D3S1358 15 18 15 18
D5S818 11 12 11 12
D6S1043 18 18
D7S820 8 12 8 12
D8S1179 12 13 12 13
D12S391 20 25 20 25
D13S317 12 14 12 14
D16S539 9 10 9 10
D18S51 16 16
D19S433 13 14 13 14
D21S11 27 28 27 28
FGA 18 21 18 21
Penta D 8 15 8 15
Penta E 7 17 7 17
TPOX 8 12 8 12
VWA 16 18 16 18
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.

Research Publications

IF=8.7
Developmental cell
IF=3.9
The Journal of biological chemistry
This KO model may be useful for: - Studying COPII-dependent vesicular trafficking and ER exit site dynamics - Investigating lysosome-dependent microautophagy pathways involving ALG2 and ESCRTs - Analyzing glycolipid transfer protein (GLTP) modulation of ER-to-Golgi transport - Functional characterization of membrane contact sites and lipid-mediated trafficking - Exploring the role of SEC31A in secretory pathway integrity and cellular stress responses

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