S100a8 Knockout RAW 264.7 Cell Line
Cat.No.:
EDJ-KZ441
Species:
Mouse
Cell Name:
RAW 264.7
Gene:
S100a8
Gene ID:
20201
Size:
1×10⁶cells
| Cat.No. | EDJ-KZ441 |
|---|---|
| Product Name | S100a8 Knockout RAW 264.7 Cell Line |
| Cell Line | RAW 264.7 |
| Cellosaurus ID | CVCL_0493 |
| Cell Line Synonyms | RAW264, RAW2647, RAW264.7, RAW-264.7, Raw 264.7, Raw264.7 |
| Gene |
S100a8
|
| NCBI Gene ID | |
| Gene Synonyms | 60B8AG|CAGA|CFAG|CGLA|CP-10|L1Ag|MA387|MIF|MRP8|NIF|P8|S100-A8 |
| Associated Diseases | Leukemia |
| QC | Indels validated by Sanger sequencing; sterility confirmed via microbial testing. |
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
| Loci | STR Info (Sample Cell) Sample Cell Line: RAW 264.7 | STR Info (Cell bank) Cell Line: RAW 264.7 | ||
| Allele1 | Allele2 | Allele1 | Allele2 | |
| 1-1 | 16 | 15 | 16 | |
| 1-2 | 17 | 17 | ||
| 2-1 | 16 | 16 | ||
| 3-2 | 14 | 14 | ||
| 4-2 | 22.3 | 22.3 | ||
| 5-5 | 14 | 15 | 14 | |
| 6-4 | 17 | 18 | 18 | |
| 6-7 | 12 | 13 | 12 | |
| 7-1 | 25.2 | 25.2 | ||
| 8-1 | 13 | 13 | ||
| 11-2 | 17 | 17 | ||
| 12-1 | 16 | 16 | ||
| 13-1 | 16.2 | 16.2 | ||
| 15-3 | 22.3 | 22.3 | ||
| 17-2 | 14 | 16 | 14 | 16 |
| 18-3 | 18 | 18 | ||
| 19-2 | 14 | 14 | ||
| X-1 | 24 | 24 | ||
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
Research Publications
A positive feedback cycle between the alarmin S100A8/A9 and NLRP3 inflammasome-GSDMD signalling reinforces the innate immune response in Candida albicans keratitis.
IF=5.4
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
B7-H3 Exacerbates Laser-induced Choroidal Neovascularization by Promoting Macrophage Recruitment and Polarization via S100A8/A9.
IF=1.9
Ophthalmic research
This KO model may be useful for:
- Investigating the role of S100a8 in macrophage recruitment and polarization in inflammatory and neovascular diseases.
- Studying the S100A8/A9-mediated positive feedback loop with NLRP3 inflammasome and GSDMD signaling in innate immune responses.
- Evaluating the contribution of S100a8 to ocular pathologies such as choroidal neovascularization and keratitis.
- Functional validation of alarmin-driven inflammatory cascades in macrophage-based in vitro models.
- Screening therapeutic candidates targeting S100A8/A9-dependent inflammatory pathways.
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Cell Culture Optimization Series
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