RNF43 Knockout HCA7 Cell Line
Cat.No.:
EDJ-KZ437
Species:
Human
Cell Name:
HCA7
Gene:
RNF43
Gene ID:
54894
Size:
1×10⁶cells
| Cat.No. | EDJ-KZ437 |
|---|---|
| Product Name | RNF43 Knockout HCA-7 Cell Line |
| Cell Line | HCA7 |
| Cellosaurus ID | CVCL_0289 |
| Cell Line Synonyms | HCA-7, HCA 7 |
| Gene | |
| NCBI Gene ID | |
| Gene Synonyms | RNF124|SSPCS|URCC |
| Summary |
The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
|
| QC | Indels validated by Sanger sequencing; sterility confirmed via microbial testing. |
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
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