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PKD2 Knockout H1 Cell Line
Cat.No.:
EDJ-KZ402
Species:
Human
Cell Name:
H1
Gene:
PKD2
Gene ID:
5311
Size:
1×10⁶cells
| Cat.No. | EDJ-KZ402 |
|---|---|
| Product Name | PKD2 Knockout H1 Cell Line |
| Species | Human |
| Cell Line | H1 |
| Cellosaurus ID | CVCL_D4YF |
| Gene | |
| NCBI Gene ID | |
| Gene Synonyms | APKD2|PC2|PKD4|Pc-2|TRPP2 |
| Summary |
This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011]
|
| Associated Diseases | Non-tumor |
| QC | Indels validated by Sanger sequencing; sterility confirmed via microbial testing. |
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
| Loci | STR Info (Sample Cell) Sample Cell Line: H1 | STR Info (Cell bank) Cell Line: H1 | ||
| Allele1 | Allele2 | Allele1 | Allele2 | |
| Amelogenin | X | Y | X | Y |
| CSF1PO | 12 | 13 | 12 | 13 |
| D2S1338 | 18 | 19 | 18 | 19 |
| D3S1358 | 15 | 15 | ||
| D5S818 | 9 | 11 | 9 | 11 |
| D7S820 | 8 | 12 | 8 | 12 |
| D8S1179 | 12 | 13 | 12 | 13 |
| D13S317 | 8 | 11 | 8 | 11 |
| D16S539 | 9 | 13 | 9 | 13 |
| D18S51 | 17 | 18 | 17 | 18 |
| D19S433 | 13 | 15 | 13 | 15 |
| D21S11 | 28 | 32.2 | 28 | 32.2 |
| FGA | 20 | 24 | 20 | 24 |
| Penta D | 10 | 13 | 10 | 13 |
| Penta E | 10 | 12 | 10 | 12 |
| TH01 | 9.3 | 9.3 | ||
| TPOX | 8 | 11 | 8 | 11 |
| vWA | 15 | 17 | 15 | 17 |
| D6S1043 | 12 | 14 | 12 | 14 |
| D12S391 | 20 | 20 | ||
| D2S441 | 10 | 11 | ||
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
Research Publications
Aldehyde dehydrogenase 1 A1 regulates the transcription of PD-L1 and its targeting with disulfiram together with PD-L1 immunotherapy synergistically delays cyst growth in ADPKD.
IF=12.6
Kidney international
This KO model may be useful for:
- Investigating the role of PKD2 in polycystic kidney disease (ADPKD) pathogenesis and cyst growth mechanisms.
- Studying the regulatory interplay between aldehyde dehydrogenase 1A1 (ALDH1A1) and PD-L1 transcription in renal epithelial cells.
- Evaluating combination therapies targeting ALDH1A1 (e.g., disulfiram) and immune checkpoint inhibitors (e.g., anti-PD-L1) for ADPKD treatment.
- Drug screening for compounds that modulate cyst expansion in a PKD2-null background.
- Exploring immune evasion pathways and tumor-like signaling in ADPKD progression.
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