KDM6B Knockout HL-60 Cell Line
Cat.No.:
EDJ-KZ306
Species:
Human
Cell Name:
HL-60
Gene:
KDM6B
Gene ID:
23135
Size:
1×10⁶cells
| Cat.No. | EDJ-KZ306 |
|---|---|
| Product Name | KDM6B Knockout HL-60 Cell Line |
| Cell Line | HL-60 |
| Cellosaurus ID | CVCL_0002 |
| Cell Line Synonyms | HL 60, HL.60, HL60, Human Leukemia-60 |
| Gene | |
| NCBI Gene ID | |
| Gene Synonyms | JMJD3|NEDCFSA|NEDSST |
| Summary |
The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27 trimethylation is a repressive epigenetic mark controlling chromatin organization and gene silencing. This protein can also demethylate non-histone proteins such as retinoblastoma protein. Through its demethylation actvity this gene influences cellular differentiation and development, tumorigenesis, inflammatory diseases, and neurodegenerative diseases. This protein has two classical nuclear localization signals at its N-terminus. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]
|
| Associated Diseases | Acute Myeloid Leukemia |
| QC | Indels validated by Sanger sequencing; sterility confirmed via microbial testing. |
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
| Loci | STR Info (Sample Cell) Sample Cell Line: HL-60 | STR Info (Cell bank) Cell Line: HL-60 | ||
| Allele1 | Allele2 | Allele1 | Allele2 | |
| Amelogenin | X | X | ||
| CSF1PO | 13 | 14 | 13 | 14 |
| D2S1338 | 17 | 17 | ||
| D3S1358 | 16 | 16 | ||
| D5S818 | 12 | 12 | ||
| D7S820 | 11 | 12 | 11 | 12 |
| D8S1179 | 12 | 13 | 12 | 13 |
| D13S317 | 8 | 11 | 8 | 11 |
| D16S539 | 11 | 11 | ||
| D18S51 | 14 | 15 | 14 | 15 |
| D19S433 | 14 | 14 | ||
| D21S11 | 29 | 30 | 29 | 30 |
| FGA | 22 | 24 | 22 | 24 |
| Penta D | 10 | 12 | 10 | 12 |
| Penta E | 13 | 14 | 13 | 14 |
| TPOX | 8 | 11 | 8 | 11 |
| vWA | 16 | 16 | ||
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
Recommended Accessories
Cell Culture Optimization Series
Related Products
CRISPR Knockout Kit
Flash CRISPR Knockout Kit（Universal Version）Flash CRISPR Knockout Kit（Universal Version）
Flash-Pro CRISPR KO Kit (For Organoids / Stem Cells)Flash-Pro CRISPR KO Kit (For Organoids / Stem Cells)
