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ERVFRD-1 Knockout BeWo Cell Line
Cat.No.:
EDJ-KZ221
Species:
Human
Cell Name:
BeWo
Gene:
ERVFRD-1
Gene ID:
405754
Size:
1×10⁶cells
| Cat.No. | EDJ-KZ221 |
|---|---|
| Product Name | ERVFRD-1 Knockout BeWo Cell Line |
| Cell Line | BeWo |
| Cellosaurus ID | CVCL_0044 |
| Cell Line Synonyms | BEWO, Be Wo, Be-Wo |
| Gene | |
| NCBI Gene ID | |
| Gene Synonyms | ERVFRDE1|GLLL6191|HERV-FRD|HERV-W/FRD|UNQ6191|envFRD |
| Summary |
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Jun 2012]
|
| QC | Indels validated by Sanger sequencing; sterility confirmed via microbial testing. |
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
| Loci | STR Info (Sample Cell) Sample Cell Line: BeWo | STR Info (Cell bank) Cell Line: BeWo | ||||
| Allele1 | Allele2 | Allele3 | Allele1 | Allele2 | Allele3 | |
| Amelogenin | X | Y | X | Y | ||
| CSF1PO | 11 | 12 | 11 | 12 | ||
| D1S1656 | 14 | 16 | 14 | 16 | ||
| D2S441 | 14 | 14 | ||||
| D2S1338 | 21 | 24 | 21 | 24 | ||
| D3S1358 | 15 | 15 | ||||
| D5S818 | 10 | 11 | 10 | 11 | ||
| D7S820 | 10 | 12 | 10 | 12 | ||
| D8S1179 | 12 | 12 | ||||
| D10S1248 | 13 | 15 | 13 | 15 | ||
| D12S391 | 17 | 24 | 17 | 24 | ||
| D13S317 | 9 | 11 | 9 | 11 | ||
| D16S539 | 13 | 14 | 13 | 14 | ||
| D18S51 | 14 | 16 | 14 | 16 | ||
| D19S433 | 13 | 15 | 13 | 15 | ||
| D21S11 | 30 | 30 | ||||
| D22S1045 | 15 | 15 | ||||
| FGA | 22 | 23 | 22 | 23 | ||
| FGA | 22 | 23 | 24 | 22 | 23 | 24 |
| Penta D | 9 | 12 | 9 | 12 | ||
| Penta E | 8 | 12 | 8 | 12 | ||
| SE33 | 15 | 25.2 | 15 | 25.2 | ||
| TH01 | 9 | 9.3 | 9 | 9.3 | ||
| TPOX | 8 | 8 | ||||
| vWA | 16 | 16 | ||||
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
Research Publications
Optimized CRISPR-based knockout in BeWo cells.
IF=2.5
Placenta
This KO model may be useful for:
- Validating CRISPR-based gene editing protocols in trophoblast models
- Investigating ERVFRD-1 function in placental cell fusion and syncytialization
- Studying endogenous retroviral envelope protein roles in cell-cell fusion pathways
- Exploring host-viral interaction mechanisms in placental biology
- Functional genomics assays for trophoblast-specific gene knockout characterization
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Cell Culture Optimization Series
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