CES1 Knockout THP-1 Cell Line
Cat.No.:
EDJ-KZ150
Species:
Human
Cell Name:
THP-1
Gene:
CES1
Gene ID:
1066
Size:
1×10⁶cells
| Cat.No. | EDJ-KZ150 |
|---|---|
| Product Name | CES1 Knockout THP-1 Cell Line |
| Cell Line | THP-1 |
| Cellosaurus ID | CVCL_0006 |
| Cell Line Synonyms | THP1, THP 1, THPI, THP-1(ATCC), THP-1-O, O-THP-1, Tohoku Hospital Pediatrics-1 |
| Gene | |
| NCBI Gene ID | |
| Gene Synonyms | ACAT|CE-1|CEH|CES2|HMSE|HMSE1|PCE-1|REH|SES1|TGH|hCE-1 |
| Summary |
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
|
| Associated Diseases | Acute Myeloid Leukemia |
| QC | Indels validated by Sanger sequencing; sterility confirmed via microbial testing. |
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
| Loci | STR Info (Sample Cell) Sample Cell Line: THP-1 | STR Info (Cell bank) Cell Line: THP-1 | ||
| Allele1 | Allele2 | Allele1 | Allele2 | |
| Amelogenin | X | Y | X | Y |
| CSF1PO | 11 | 13 | 11 | 13 |
| D1S1656 | 16 | 17 | 16 | 17 |
| D2S1338 | 17 | 18 | 17 | 18 |
| D3S1358 | 15 | 17 | 15 | 17 |
| D5S818 | 11 | 12 | 11 | 12 |
| D7S820 | 10 | 10 | ||
| D8S1179 | 10 | 14 | 10 | 14 |
| D12S391 | 19 | 18 | 19 | |
| D13S317 | 13 | 13 | ||
| D16S539 | 11 | 12 | 11 | 12 |
| D18S51 | 13 | 14 | 13 | 14 |
| D19S433 | 12.2 | 13 | 12.2 | 13 |
| D21S11 | 30 | 31.2 | 30 | 31.2 |
| FGA | 24 | 25 | 24 | 25 |
| Penta D | 10 | 12 | 10 | 12 |
| Penta E | 11 | 15 | 11 | 15 |
| TH01 | 8 | 9.3 | 8 | 9.3 |
| TPOX | 8 | 11 | 8 | 11 |
| VWA | 16 | 16 | ||
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
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