CD47 Knockout MC-38 Cell Line
Cat.No.:
EDJ-KZ142
Species:
Mouse
Cell Name:
MC-38
Gene:
CD47
Gene ID:
961
Size:
1×10⁶cells
| Cat.No. | EDJ-KZ142 |
|---|---|
| Product Name | CD47 Knockout MC38 Cell Line |
| Species | Mouse |
| Cell Line | MC-38 |
| Cellosaurus ID | CVCL_B288 |
| Cell Line Synonyms | MCA-38, MCA 38, MCA38, MC38, MC-38 B/6, Mouse Colon 38, Murine Carcinoma-38, Colon-38, Colon 38, Colon38, C38 |
| Gene | CD47 |
| Gene Synonyms | IAP|MER6|OA3 |
| Summary |
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
|
| QC | Indels validated by Sanger sequencing; sterility confirmed via microbial testing. |
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
| Loci | STR Info (Sample Cell) Sample Cell Line: MC-38 | STR Info (Cell bank) Cell Line: MC-38 | ||
| Allele1 | Allele2 | Allele1 | Allele2 | |
| 1-1 | 16 | 16 | ||
| 1-2 | 19 | 19 | ||
| 2-1 | 16 | 16 | ||
| 3-2 | 13 | 14 | 13 | 14 |
| 4-2 | 20.3 | 20.3 | ||
| 5-5 | 17 | 17 | ||
| 6-4 | 18 | 18 | ||
| 6-7 | 14 | 15 | 14 | 15 |
| 7-1 | 26.2 | 26.2 | ||
| 8-1 | 16 | 17 | 16 | 17 |
| 11-2 | 16 | 16 | ||
| 12-1 | 17 | 17 | ||
| 13-1 | 17.1 | 17.1 | ||
| 15-3 | 22.3 | 22.3 | ||
| 17-2 | 15 | 15 | ||
| 18-3 | 16 | 16 | ||
| 19-2 | 13 | 13 | ||
| X-1 | 27 | 27 | ||
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
Related Publications
FACS-based genome-wide CRISPR screening platform identifies modulators of CD47.
IF=5.9
Frontiers in immunology
This KO model may be useful for:
- Genome-wide CRISPR screening to identify modulators of CD47 expression and function
- Functional validation of CD47 in immune evasion and phagocytosis regulation
- Drug screening for therapeutic agents targeting the CD47-SIRPα axis
- Mechanistic studies of CD47-mediated signaling in tumor microenvironment
- Flow cytometry-based assays for evaluating immune checkpoint interactions
Required Accessories
Cell Culture Optimization Series
Related Products
CRISPR Knockout Kit
Flash CRISPR Knockout Kit（Universal Version）Flash CRISPR Knockout Kit（Universal Version）
Flash-Pro CRISPR KO Kit (For Organoids / Stem Cells)Flash-Pro CRISPR KO Kit (For Organoids / Stem Cells)
