ATF1 Knockout LoVo Cell Line
Cat.No.:
EDJ-KZ557
Species:
Human
Cell Name:
LoVo
Gene:
ATF1
Gene ID:
466
Size:
1×10⁶cells
| Cat.No. | EDJ-KZ557 |
|---|---|
| Product Name | ATF1 Knockout LoVo Cell Line |
| Cell Line | LoVo |
| Cellosaurus ID | CVCL_0399 |
| Cell Line Synonyms | LOVO |
| Gene | |
| NCBI Gene ID | |
| Gene Synonyms | EWS-ATF1|FUS/ATF-1|TREB36 |
| Summary |
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]
|
| Associated Diseases | Colorectal Carcinoma |
| QC | Indels validated by Sanger sequencing; sterility confirmed via microbial testing. |
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
| Loci | STR Info (Sample Cell) Sample Cell Line: LoVo | STR Info (Cell bank) Cell Line: LoVo | ||||||
| Allele1 | Allele2 | Allele3 | Allele4 | Allele1 | Allele2 | Allele3 | Allele4 | |
| Amelogenin | X | Y | X | Y | ||||
| CSF1PO | 10 | 11 | 13 | 14 | 10 | 11 | 13 | 14 |
| D2S1338 | 17 | 18 | 16 | 17 | 18 | |||
| D3S1358 | 14 | 17 | 18 | 14 | 15 | 16 | 17 | |
| D5S818 | 11 | 13 | 11 | 13 | ||||
| D7S820 | 9.3 | 10 | 11 | 9.3 | 10 | 11 | ||
| D8S1179 | 10 | 10 | ||||||
| D13S317 | 8 | 11 | 8 | 11 | ||||
| D16S539 | 9 | 12 | 9 | 11 | 12 | |||
| D18S51 | 13 | 18 | 13 | 17 | 18 | |||
| D19S433 | 14 | 15 | 14 | 15 | ||||
| D21S11 | 29 | 31.2 | 29 | 31.2 | ||||
| FGA | 18 | 20 | 18 | 20 | ||||
| Penta D | 10 | 14 | 10 | 14 | ||||
| Penta E | 10 | 16 | 10 | 16 | ||||
| TH01 | 9.3 | 9.3 | ||||||
| TPOX | 8 | 9 | 8 | 9 | ||||
| vWA | 17 | 18 | 17 | 18 | ||||
| D6S1043 | 11 | 17 | ||||||
| D12S391 | 20 | 22 | 23 | |||||
| D2S441 | 13 | 14 | ||||||
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
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