SLC2A11
Solute Carrier Family 2 Member 11
Gene Information Card
| Symbol | SLC2A11 |
|---|---|
| Full Name | Solute Carrier Family 2 Member 11 |
| Gene Type | protein-coding |
| Chromosomal Location | 22q11.23 |
| NCBI Gene ID | 66035 ncbi.nlm.nih.gov/gene/66035 |
| Ensembl ID | ENSG00000100290 |
| UniProt ID | Q9BYW1 |
| OMIM ID | 610367 |
| HGNC ID | 10978 |
| Aliases | GLUT11, GLUT10, SLC2A10 (note: SLC2A10 is a distinct gene; SLC2A11 is also known as GLUT11) |
Description
SLC2A11 encodes a member of the facilitative glucose transporter family (GLUTs). The encoded protein, GLUT11, is a glucose transporter that mediates the uptake of glucose and other hexoses. It is expressed in multiple tissues and may play a role in glucose homeostasis. Alternative splicing generates multiple transcript variants.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Diabetes Mellitus, Type 2 | Potential association with altered glucose transport; SLC2A11 variants may influence insulin sensitivity | Limited evidence from association studies; not yet confirmed in large cohorts |
| Obesity | Altered expression in adipose tissue may contribute to metabolic dysregulation | Observational studies; no direct causal mechanism established |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 5.2 | Medium |
| Heart | 3.8 | Low |
| Skeletal muscle | 4.1 | Low |
| Kidney | 6.0 | Medium |
| Liver | 2.5 | Low |
| Pancreas | 1.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 2.3 | Hepatocellular carcinoma cell line |
| HEK 293 | 1.5 | Embryonic kidney cells |
| MCF7 | 0.8 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1045C>T (p.Arg349Trp) | Missense | <0.01% | Unknown; predicted possibly damaging |
| c.1234G>A (p.Gly412Ser) | Missense | <0.01% | Unknown; predicted benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No gain-of-function mutations described.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005355 - glucose transmembrane transporter activity | • GO:0015758 - glucose transport |
| • GO:0005887 - integral component of plasma membrane | • GO:0055085 - transmembrane transport |
Pathways
• Glucose transport (Reactome: R-HSA-189200)
• SLC-mediated transmembrane transport (Reactome: R-HSA-425407)
Protein Summary
GLUT11 is a 496-amino acid facilitative glucose transporter with 12 transmembrane domains. It transports glucose and fructose with low affinity. The protein is localized to the plasma membrane and is expressed in various tissues, including adipose, heart, and kidney. Its physiological role in glucose homeostasis is not fully elucidated.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC2A11 Knockout HEK293 Cell Line | EDC08368 | Human | 66035 | Details Get a Quote |
| SLC2A11 Knockout HeLa Cell Line | EDJ-KQ57118 | Human | 66035 | Details Get a Quote |
| SLC2A11 Knockout A-549 Cell Line | EDJ-KQ65632 | Human | 66035 | Details Get a Quote |
| SLC2A11 Knockout HCT 116 Cell Line | EDC07725 | Human | 66035 | Details Get a Quote |
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