SENP7 Gene - Sentrin/SUMO-Specific Protease 7
Functional annotation, expression, and clinical relevance of SENP7
Gene Information Card
| Symbol | SENP7 |
|---|---|
| Full Name | SUMO specific peptidase 7 |
| Gene Type | protein-coding |
| Chromosomal Location | 3q29 |
| NCBI Gene ID | 57337 ncbi.nlm.nih.gov/gene/57337 |
| Ensembl ID | ENSG00000138413 |
| UniProt ID | Q9BQF6 |
| OMIM ID | 612845 |
| HGNC ID | 21557 |
| Aliases | KIAA1707, SUMO1/sentrin specific peptidase 7, SUMO-specific protease 7 |
Description
SENP7 (SUMO specific peptidase 7) encodes a member of the sentrin/SUMO-specific protease family. The protein catalyzes the deconjugation of SUMO (small ubiquitin-like modifier) from target proteins, regulating processes such as chromatin remodeling, DNA repair, and transcriptional control. SENP7 is localized to the nucleus and is involved in the deSUMOylation of histone deacetylases and other chromatin-associated factors.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | SENP7 overexpression correlates with poor prognosis; modulates SUMOylation of chromatin regulators | PMID: 25605274 |
| Colorectal cancer | SENP7 promotes cell proliferation via deSUMOylation of HDAC2 | PMID: 28878319 |
| Hepatocellular carcinoma | SENP7 upregulation associated with tumor progression and metastasis | PMID: 31065109 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 8.3 | Low |
| Brain | 6.1 | Low |
| Liver | 5.4 | Low |
| Kidney | 4.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | Embryonic kidney cells |
| HeLa | 10.8 | Cervical carcinoma |
| MCF7 | 9.1 | Breast cancer |
| HepG2 | 7.3 | Hepatocellular carcinoma |
| A549 | 6.5 | Lung carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Trp) | Missense | 0.01% (gnomAD) | Unknown functional impact |
| c.567_568insA (p.Glu190Argfs*12) | Frameshift | Rare | Predicted loss of function |
| c.2101G>A (p.Gly701Ser) | Missense | 0.005% (gnomAD) | Reduced catalytic activity in vitro |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense variants that truncate the catalytic domain are predicted to abolish SUMO protease activity.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in literature or databases.
Dominant Negative (DN)
Not described; dominant-negative effects have not been experimentally validated for SENP7.
View complete mutation data：
Gene Ontology (GO)
| • SUMO-specific protease activity (GO:0016929) | • nucleus (GO:0005634) |
| • protein desumoylation (GO:0016926) | • DNA binding (GO:0003677) |
| • chromatin remodeling (GO:0006338) |
Pathways
• SUMOylation (Reactome: R-HSA-2990846)
• Chromatin modifying enzymes (Reactome: R-HSA-3247509)
• SUMO E3 ligases SUMOylate target proteins (Reactome: R-HSA-3108232)
Protein Summary
SENP7 is a 984-amino acid nuclear protease that specifically removes SUMO2/3 chains from target proteins. It contains a conserved C-terminal peptidase domain (C48 family) and an N-terminal regulatory region. SENP7 plays a key role in chromatin decondensation by deSUMOylating HDAC2 and other repressive complexes, thereby influencing gene expression and DNA repair. Its dysregulation is implicated in several cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SENP7 Knockout HEK293 Cell Line | EDJ-KQ15224 | Human | 57337 | Details Get a Quote |
| SENP7 Knockout A-549 Cell Line | EDJ-KQ45882 | Human | 57337 | Details Get a Quote |
| SENP7 Knockout HCT 116 Cell Line | EDJ-KQ45883 | Human | 57337 | Details Get a Quote |
| SENP7 Knockout HeLa Cell Line | EDJ-KQ45884 | Human | 57337 | Details Get a Quote |
| SENP7 Knockout SK-BR-3 Cell Line | EDJ-KZ448 | Human | 57337 | Details Get a Quote |
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