SELENOH: Selenoprotein H
A nucleolar selenoprotein involved in redox regulation and neuroprotection
Gene Information Card
| Symbol | SELENOH |
|---|---|
| Full Name | Selenoprotein H |
| Gene Type | Protein coding |
| Chromosomal Location | 11q12.1 |
| NCBI Gene ID | 64132 ncbi.nlm.nih.gov/gene/64132 |
| Ensembl ID | ENSG00000149257 |
| UniProt ID | Q8IZQ5 |
| OMIM ID | 607234 |
| HGNC ID | 30368 |
| Aliases | SELH, C11orf31, HSPC111 |
Description
SELENOH encodes selenoprotein H, a nucleolar selenoprotein that contains a selenocysteine (Sec) residue encoded by the UGA codon. It functions as a redox sensor and transcriptional regulator, protecting cells from oxidative stress by modulating glutathione levels and mitochondrial function. SELENOH is highly expressed in the brain and is implicated in neuroprotection, immune response, and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Downregulation of SELENOH increases oxidative stress and promotes tumorigenesis | PMID: 23299887 |
| Neurodegenerative Disorders | SELENOH protects neurons from oxidative damage; reduced expression linked to Alzheimer's disease | PMID: 17609215 |
| Cardiovascular Disease | SELENOH deficiency impairs redox balance in cardiac cells | PMID: 24878593 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 9.7 | Low |
| Testis | 15.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.4 | Embryonic kidney cells |
| SH-SY5Y | 14.1 | Neuroblastoma cells |
| HepG2 | 7.8 | Hepatocellular carcinoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337G>A (p.Gly113Arg) | Missense | <0.01% | Unknown functional effect |
| c.424T>C (p.Ser142Pro) | Missense | <0.01% | Potential loss of redox activity |
Mutation functional classification
Loss of Function (LOF)
Missense variants in the selenocysteine insertion sequence (SECIS) may impair selenoprotein synthesis.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • nucleolus (GO:0005730) | • response to oxidative stress (GO:0006979) |
| • cell redox homeostasis (GO:0045454) | • selenium binding (GO:0008430) |
| • oxidoreductase activity (GO:0016491) |
Pathways
• Selenium micronutrient network
• Oxidative stress response
Protein Summary
Selenoprotein H is a 14 kDa nucleolar protein containing a single selenocysteine residue. It acts as a redox-sensitive transcription factor, upregulating antioxidant genes such as glutathione S-transferase and thioredoxin reductase. SELENOH is essential for maintaining cellular redox balance and mitochondrial integrity, particularly in neuronal tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SELENOH Knockout HEK293 Cell Line | EDJ-KQ15215 | Human | 280636 | Details Get a Quote |
| SELENOH Knockout HCT 116 Cell Line | EDJ-KQ45869 | Human | 280636 | Details Get a Quote |
| SELENOH Knockout HeLa Cell Line | EDJ-KQ45870 | Human | 280636 | Details Get a Quote |
| SELENOH Knockout A-549 Cell Line | EDJ-KQ48055 | Human | 280636 | Details Get a Quote |
