PVRIG
PVR Related Immunoglobulin Domain Containing Gene
Gene Information Card
| Symbol | PVRIG |
|---|---|
| Full Name | PVR Related Immunoglobulin Domain Containing |
| Gene Type | protein-coding |
| Chromosomal Location | 5q35.3 |
| NCBI Gene ID | 79037 ncbi.nlm.nih.gov/gene/79037 |
| Ensembl ID | ENSG00000113407 |
| UniProt ID | Q6DKI7 |
| OMIM ID | 617012 |
| HGNC ID | 26406 |
| Aliases | CD112R, C7orf15, MGC2463 |
Description
PVRIG (PVR related immunoglobulin domain containing) encodes a transmembrane protein that functions as an immune checkpoint receptor. It is expressed on T cells and NK cells and binds to its ligand PVRL2 (nectin-2/CD112) on antigen-presenting cells and tumor cells, inhibiting T cell and NK cell activation. PVRIG is a target for cancer immunotherapy.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | PVRIG binding to PVRL2 on tumor cells inhibits anti-tumor immune responses | PMID: 31000564 |
| Autoimmune diseases | Potential role in T cell regulation; overexpression may contribute to immune exhaustion | PMID: 32015547 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tonsil | 2.3 | Low |
| Lymph node | 1.8 | Low |
| Spleen | 1.5 | Low |
| Bone marrow | 0.9 | Not detected |
| Thymus | 0.7 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Jurkat (T cell leukemia) | 2.1 | Moderate expression |
| K562 (leukemia) | 0.5 | Low expression |
| HEK293 (embryonic kidney) | 0.3 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487G>A (p.Gly163Arg) | Missense | <0.01% | Unknown significance |
| c.101C>T (p.Thr34Met) | Missense | <0.01% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • GO:0004888 - transmembrane signaling receptor activity | • GO:0007165 - signal transduction |
| • GO:0005886 - plasma membrane | • GO:0009897 - external side of plasma membrane |
| • GO:0050776 - regulation of immune response |
Pathways
• Immune checkpoint signaling (PVRIG-PVRL2 pathway)
• T cell receptor signaling pathway (inhibition)
Protein Summary
PVRIG is a type I transmembrane protein with a single extracellular immunoglobulin-like domain. It acts as an inhibitory receptor on T cells and NK cells. Binding to PVRL2 (CD112) on target cells suppresses immune activation, making it a checkpoint target for cancer immunotherapy.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PVRIG Knockout HEK293 Cell Line | EDC07584 | Human | 79037 | Details Get a Quote |
| PVRIG Knockout A-549 Cell Line | EDJ-KQ19807 | Human | 79037 | Details Get a Quote |
| PVRIG Knockout HeLa Cell Line | EDJ-KQ19808 | Human | 79037 | Details Get a Quote |
| PVRIG Knockout HCT 116 Cell Line | EDJ-KQ74073 | Human | 79037 | Details Get a Quote |
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