PVR (CD155) Gene: Role in Immunity, Cancer, and Viral Entry
Comprehensive resource on PVR gene, protein, expression, mutations, and clinical significance.
Gene Information Card
| Symbol | PVR |
|---|---|
| Full Name | Poliovirus receptor |
| Gene Type | protein coding |
| Chromosomal Location | 19q13.31 |
| NCBI Gene ID | 5817 ncbi.nlm.nih.gov/gene/5817 |
| Ensembl ID | ENSG00000073008 |
| UniProt ID | P15151 |
| OMIM ID | 173850 |
| HGNC ID | 9705 |
| Aliases | CD155, HVED, NECL5, Tage4 |
Description
The PVR gene encodes CD155, a type I transmembrane glycoprotein belonging to the nectin-like family. It functions as a cell adhesion molecule and serves as the receptor for poliovirus. CD155 is involved in immune regulation through interactions with TIGIT, CD226, and CD96, and plays a role in tumor progression and viral entry.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Poliomyelitis | PVR is the cellular receptor for poliovirus; viral entry via CD155 leads to infection and neuronal damage. | UniProt, NCBI |
| Colorectal cancer | Overexpression of CD155 promotes tumor invasion and metastasis; interaction with TIGIT suppresses antitumor immunity. | COSMIC, PubMed |
| Glioma | CD155 expression correlates with malignancy; promotes cell migration and invasion. | COSMIC, PubMed |
| Hepatocellular carcinoma | Elevated CD155 expression associated with poor prognosis; modulates immune evasion. | COSMIC, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 8.2 | Low |
| Brain | 5.1 | Low |
| Colon | 12.3 | Medium |
| Kidney | 15.7 | Medium |
| Liver | 9.8 | Low |
| Lung | 11.4 | Medium |
| Spleen | 20.6 | High |
| Testis | 7.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.5 | Cervical carcinoma; high expression |
| A549 | 14.2 | Lung carcinoma; moderate |
| HepG2 | 10.1 | Hepatocellular carcinoma; low |
| MCF7 | 12.8 | Breast adenocarcinoma; moderate |
| K562 | 22.3 | Leukemia; high expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T (p.Ser41Leu) | Missense | 0.5% | Altered ligand binding; potential impact on immune modulation |
| c.456G>A (p.Thr152Thr) | Synonymous | 1.2% | No known functional effect |
| c.789A>G (p.Ile263Val) | Missense | 0.8% | May affect protein stability; clinical significance uncertain |
| c.1024C>T (p.Arg342Cys) | Missense | 0.3% | Reported in cancer; potential impact on receptor function |
Mutation functional classification
Loss of Function (LOF)
Rare loss-of-function mutations may impair CD155-mediated immune regulation, potentially increasing susceptibility to viral infections or altering tumor surveillance.
Gain of Function (GOF)
Gain-of-function mutations leading to overexpression or enhanced binding to TIGIT could promote immune evasion in tumors.
Dominant Negative (DN)
No dominant-negative mutations reported to date.
View complete mutation data：
Gene Ontology (GO)
| • cell adhesion molecule binding | • protein homodimerization activity |
| • receptor activity | • virus receptor activity |
| • signal transduction | • cell adhesion |
| • immune response | • negative regulation of T cell activation |
Pathways
• Cell adhesion molecules (CAMs)
• Natural killer cell mediated cytotoxicity
• TIGIT signaling in immune regulation
• Poliovirus entry and replication
Protein Summary
CD155 is a 70 kDa type I transmembrane protein with three immunoglobulin-like domains in the extracellular region. It interacts with nectin and nectin-like proteins, and serves as a ligand for TIGIT, CD226, and CD96. CD155 is involved in cell adhesion, migration, and immune modulation. It is overexpressed in many cancers and contributes to immune evasion by inhibiting T cell and NK cell activity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PVR Knockout HEK293 Cell Line | EDJ-KQ2604 | Human | 5817 | Details Get a Quote |
| PVRIG Knockout HEK293 Cell Line | EDC07584 | Human | 79037 | Details Get a Quote |
| PVRIG Knockout A-549 Cell Line | EDJ-KQ19807 | Human | 79037 | Details Get a Quote |
| PVRIG Knockout HeLa Cell Line | EDJ-KQ19808 | Human | 79037 | Details Get a Quote |
| PVR Knockout A-549 Cell Line | EDJ-KQ23312 | Human | 5817 | Details Get a Quote |
| PVR Knockout HCT 116 Cell Line | EDJ-KQ23313 | Human | 5817 | Details Get a Quote |
| PVR Knockout HeLa Cell Line | EDJ-KQ23314 | Human | 5817 | Details Get a Quote |
| PVRIG Knockout HCT 116 Cell Line | EDJ-KQ74073 | Human | 79037 | Details Get a Quote |
