PIM1 Gene: Proto-Oncogene, Serine/Threonine Kinase
PIM1 encodes a serine/threonine kinase involved in cell survival, proliferation, and differentiation, with implications in hematological malignancies and solid tumors.
Gene Information Card
| Symbol | PIM1 |
|---|---|
| Full Name | Pim-1 proto-oncogene, serine/threonine kinase |
| Gene Type | protein coding |
| Chromosomal Location | 6p21.2 |
| NCBI Gene ID | 5292 ncbi.nlm.nih.gov/gene/5292 |
| Ensembl ID | ENSG00000137193 |
| UniProt ID | P11309 |
| OMIM ID | 164960 |
| HGNC ID | 8986 |
| Aliases | PIM, PIM1 kinase |
Description
PIM1 is a proto-oncogene encoding a serine/threonine kinase that regulates cell cycle progression, apoptosis, and transcriptional activation. It is overexpressed in various cancers, particularly hematological malignancies, and is a target for therapeutic inhibition.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | PIM1 overexpression promotes cell survival and proliferation via phosphorylation of substrates like BAD and MYC. | PMID: 15696208; COSMIC |
| Diffuse large B-cell lymphoma | Somatic mutations and overexpression of PIM1 contribute to lymphomagenesis through NF-κB pathway activation. | PMID: 21965290; COSMIC |
| Acute myeloid leukemia | PIM1 is overexpressed and cooperates with FLT3-ITD mutations to enhance leukemic cell growth. | PMID: 16912225; COSMIC |
| Gastric cancer | PIM1 upregulation correlates with poor prognosis and promotes tumor invasion via epithelial-mesenchymal transition. | PMID: 25847142; COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Lymph node | 8.7 | Low |
| Testis | 6.3 | Low |
| Brain | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 (leukemia) | 15.3 | High expression |
| MCF7 (breast cancer) | 8.1 | Moderate |
| A549 (lung cancer) | 5.4 | Low |
| HepG2 (liver cancer) | 3.2 | Low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.556C>T (p.Arg186Cys) | Missense | 0.5% in COSMIC | Potential gain-of-function; observed in lymphoma |
| c.680A>G (p.Gln227Arg) | Missense | 0.3% in COSMIC | Unknown; in solid tumors |
| c.1000C>T (p.Arg334Trp) | Missense | 0.2% in COSMIC | Likely loss-of-function; reduced kinase activity |
| c.1123_1124insA (frameshift) | Insertion | 0.1% in COSMIC | Loss-of-function; truncation |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations that truncate the kinase domain, reducing catalytic activity.
Gain of Function (GOF)
Missense mutations in the kinase domain that increase phosphorylation activity, promoting oncogenic signaling.
Dominant Negative (DN)
Not well documented; some mutations may interfere with dimerization, but evidence is limited.
View complete mutation data：
Gene Ontology (GO)
| • protein serine/threonine kinase activity | • ATP binding |
| • protein phosphorylation | • cell proliferation |
| • apoptotic process | • signal transduction |
Pathways
• JAK-STAT signaling pathway
• MAPK signaling pathway
• PI3K-Akt signaling pathway
• Cytokine-cytokine receptor interaction
Protein Summary
PIM1 is a 313-amino acid serine/threonine kinase that phosphorylates substrates involved in cell cycle progression (e.g., CDC25A), apoptosis (BAD), and transcription (MYC). It is constitutively active and regulated by cytokines and growth factors. Overexpression in cancers promotes survival and drug resistance, making it a therapeutic target.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PIM1 Knockout HEK293 Cell Line | EDJ-KQ14767 | Human | 5292 | Details Get a Quote |
| PIM1 Knockout A-549 Cell Line | EDJ-KQ18104 | Human | 5292 | Details Get a Quote |
| PIM1 Knockout HeLa Cell Line | EDJ-KQ43918 | Human | 5292 | Details Get a Quote |
| PIM1 Knockout HCT 116 Cell Line | EDJ-KQ45165 | Human | 5292 | Details Get a Quote |
| PIM1 Knockout NCI-H1299 Cell Line | EDJ-KZ40 | Human | 5292 | Details Get a Quote |
