MMP11 (Matrix Metallopeptidase 11)
Stromelysin-3: A Key Regulator in Extracellular Matrix Remodeling and Cancer Progression
Gene Information Card
| Symbol | MMP11 |
|---|---|
| Full Name | Matrix Metallopeptidase 11 |
| Gene Type | Protein coding |
| Chromosomal Location | 22q11.23 |
| NCBI Gene ID | 4320 ncbi.nlm.nih.gov/gene/4320 |
| Ensembl ID | ENSG00000100053 |
| UniProt ID | P24347 |
| OMIM ID | 185261 |
| HGNC ID | 7157 |
| Aliases | SL-3, ST3, STMY3 |
Description
MMP11 (Matrix Metallopeptidase 11), also known as stromelysin-3, encodes a member of the matrix metalloproteinase (MMP) family. Unlike most MMPs, MMP11 is secreted as a proenzyme and activated extracellularly by furin. It plays a role in extracellular matrix remodeling, cell growth, and tissue repair. Overexpression is associated with various cancers and fibrotic diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Carcinoma | Overexpression promotes tumor invasion and metastasis via ECM degradation | PMID: 10646886 |
| Colorectal Cancer | Elevated MMP11 correlates with poor prognosis and lymph node metastasis | PMID: 19029980 |
| Lung Cancer | MMP11 expression enhances stromal remodeling and tumor progression | PMID: 21558396 |
| Osteoarthritis | MMP11 contributes to cartilage degradation in joint disease | PMID: 10700367 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Placenta | 12.5 | Medium |
| Lung | 8.3 | Low |
| Breast | 6.1 | Low |
| Colon | 4.7 | Low |
| Prostate | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (Breast cancer) | 15.2 | High expression |
| A549 (Lung cancer) | 9.8 | Moderate expression |
| HT-29 (Colorectal cancer) | 7.4 | Moderate expression |
| HEK 293 (Embryonic kidney) | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.832G>A (p.Glu278Lys) | Missense | <0.01% | Unknown functional impact |
| c.1045C>T (p.Arg349Trp) | Missense | <0.01% | Reported in COSMIC; potential loss of function |
| c.1234_1235insA | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations are predicted to cause loss of proteolytic activity.
Gain of Function (GOF)
Missense mutations in the catalytic domain may alter substrate specificity, but evidence is limited.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for MMP11.
View complete mutation data：
Gene Ontology (GO)
| • GO:0004222 - metalloendopeptidase activity | • GO:0005578 - extracellular matrix |
| • GO:0006508 - proteolysis | • GO:0030574 - collagen catabolic process |
| • GO:0005615 - extracellular space |
Pathways
• Matrix Metalloproteinases (MMPs) pathway
• Extracellular matrix organization
• Degradation of the extracellular matrix
Protein Summary
MMP11 (stromelysin-3) is a 488-amino acid secreted metalloproteinase with a signal peptide, prodomain, catalytic domain containing the zinc-binding motif, and a hemopexin-like domain. It is activated by furin cleavage and degrades extracellular matrix components such as fibronectin, laminin, and collagen IV. Unlike other MMPs, it is not inhibited by TIMPs. Overexpression in tumors correlates with poor prognosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MMP11 Knockout MIA PaCa-2 Cell Line | EDJ-KQ58 | Human | 4320 | Details Get a Quote |
| MMP11 Knockout HEK293 Cell Line | EDJ-KQ1930 | Human | 4320 | Details Get a Quote |
| MMP11 Knockout HCT 116 Cell Line | EDJ-KQ21856 | Human | 4320 | Details Get a Quote |
| MMP11 Knockout HeLa Cell Line | EDJ-KQ21857 | Human | 4320 | Details Get a Quote |
| MMP11 Knockout A-549 Cell Line | EDJ-KQ62378 | Human | 4320 | Details Get a Quote |
| MMP11 Knockout HAP1 Cell Line | EDC07974 | Human | 4320 | Details Get a Quote |
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