MINPP1: Multiple Inositol Polyphosphate Phosphatase 1
A key regulator of inositol phosphate metabolism and calcium signaling
Gene Information Card
| Symbol | MINPP1 |
|---|---|
| Full Name | Multiple Inositol Polyphosphate Phosphatase 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 10q23.33 |
| NCBI Gene ID | 9562 ncbi.nlm.nih.gov/gene/9562 |
| Ensembl ID | ENSG00000107779 |
| UniProt ID | Q9UNW1 |
| OMIM ID | 605391 |
| HGNC ID | 7102 |
| Aliases | MIPP, MINPP2, hMIPP |
Description
MINPP1 encodes multiple inositol polyphosphate phosphatase 1, an enzyme that hydrolyzes inositol phosphates, including inositol hexakisphosphate (InsP6) and inositol 1,3,4,5,6-pentakisphosphate (InsP5). It plays a role in inositol phosphate metabolism, calcium signaling, and cellular phosphate homeostasis. The gene is located on chromosome 10q23.33 and is expressed in various tissues, with highest levels in the brain, kidney, and testis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | MINPP1 expression is reduced in prostate cancer; loss may contribute to tumor progression via altered inositol phosphate signaling. | PMID: 14559847 |
| Colorectal cancer | MINPP1 hypermethylation and reduced expression observed in colorectal tumors, suggesting a tumor suppressor role. | PMID: 19029980 |
| Hepatocellular carcinoma | MINPP1 downregulation associated with poor prognosis; may affect cell proliferation and migration. | PMID: 25636847 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Kidney | 10.2 | Medium |
| Testis | 8.9 | Medium |
| Liver | 5.3 | Low |
| Heart | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | High expression |
| HeLa | 8.5 | Moderate expression |
| HepG2 | 6.2 | Low expression |
| MCF7 | 4.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | Rare | Likely loss of function |
| c.100C>T (p.Arg34Trp) | Missense | Rare | Unknown significance |
| c.200G>A (p.Arg67Gln) | Missense | Rare | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
MINPP1 loss-of-function mutations are rare but may impair inositol phosphate hydrolysis, potentially contributing to cancer progression.
Gain of Function (GOF)
No gain-of-function mutations reported in MINPP1.
Dominant Negative (DN)
No dominant-negative mutations reported in MINPP1.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Inositol phosphate metabolism (KEGG: map00562)
• Phosphatidylinositol signaling system (KEGG: map04070)
Protein Summary
MINPP1 encodes a 499-amino acid protein with a molecular weight of approximately 55 kDa. It belongs to the histidine acid phosphatase family and localizes to the cytoplasm. The enzyme catalyzes the dephosphorylation of inositol hexakisphosphate (InsP6) and inositol pentakisphosphate (InsP5), generating lower inositol phosphates that regulate calcium signaling and cellular phosphate balance. Structural studies reveal a conserved active site with a histidine residue critical for catalysis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MINPP1 Knockout HEK293 Cell Line | EDJ-KQ6640 | Human | 9562 | Details Get a Quote |
| MINPP1 Knockout A-549 Cell Line | EDJ-KQ30904 | Human | 9562 | Details Get a Quote |
| MINPP1 Knockout HCT 116 Cell Line | EDJ-KQ30905 | Human | 9562 | Details Get a Quote |
| MINPP1 Knockout HeLa Cell Line | EDJ-KQ30906 | Human | 9562 | Details Get a Quote |
