CHST10: Carbohydrate Sulfotransferase 10
A key enzyme in HNK-1 carbohydrate epitope biosynthesis, involved in cell adhesion and neural development.
Gene Information Card
| Symbol | CHST10 |
|---|---|
| Full Name | Carbohydrate Sulfotransferase 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q11.2 |
| NCBI Gene ID | 9486 ncbi.nlm.nih.gov/gene/9486 |
| Ensembl ID | ENSG00000115526 |
| UniProt ID | O43529 |
| OMIM ID | 606376 |
| HGNC ID | 1925 |
| Aliases | HNK1ST, HNK-1ST, HNK-1 sulfotransferase |
Description
CHST10 encodes a sulfotransferase enzyme that catalyzes the transfer of sulfate to the HNK-1 (human natural killer-1) carbohydrate epitope. This modification is critical for cell-cell and cell-matrix interactions, particularly in the nervous system. The enzyme is involved in neural development, synaptic plasticity, and immune cell adhesion.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hereditary spastic paraplegia (potential) | Loss of CHST10 function may impair sulfation of HNK-1 epitopes on neural glycoproteins, disrupting axonal guidance and myelination. | Limited; inferred from functional studies and homology to other sulfotransferases. |
| Cancer (various) | Altered HNK-1 expression and CHST10 activity may influence tumor cell adhesion and metastasis. | Expression data from COSMIC; direct mechanistic evidence limited. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 8.5 | Medium |
| Testis | 4.2 | Low |
| Kidney | 3.1 | Low |
| Lung | 2.0 | Low |
| Liver | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 6.8 | Neuronal model |
| HEK293 (embryonic kidney) | 4.5 | Common expression system |
| A549 (lung carcinoma) | 2.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T (p.Arg163Trp) | Missense | 0.01% (gnomAD) | Unknown; predicted damaging by SIFT |
| c.1024G>A (p.Val342Met) | Missense | 0.005% (gnomAD) | Unknown; predicted benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • N-acetylglucosamine 6-O-sulfotransferase activity (GO:0001517) | • Golgi apparatus (GO:0005794) |
| • N-acetylglucosamine metabolic process (GO:0006044) | • protein sulfation (GO:0006477) |
| • peptide cross-linking (GO:0018149) |
Pathways
• ['HNK-1 biosynthesis'
• 'Reactome: R-HSA-975634']
• ['Sulfur metabolism'
• 'KEGG: map00920']
Protein Summary
CHST10 is a type II transmembrane Golgi protein of 356 amino acids. It catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the terminal N-acetylglucosamine of the HNK-1 glycan. The enzyme is essential for the biosynthesis of the HNK-1 carbohydrate epitope, which is expressed on neural cell adhesion molecules (NCAMs) and other glycoproteins. HNK-1 sulfation modulates cell adhesion, neurite outgrowth, and synaptic plasticity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CHST10 Knockout HEK293 Cell Line | EDJ-KQ6605 | Human | 9486 | Details Get a Quote |
| CHST10 Knockout A-549 Cell Line | EDJ-KQ30836 | Human | 9486 | Details Get a Quote |
| CHST10 Knockout HeLa Cell Line | EDJ-KQ30837 | Human | 9486 | Details Get a Quote |
| CHST10 Knockout HCT 116 Cell Line | EDJ-KQ72116 | Human | 9486 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
