Overview
Safe Harbor Loci
Study and characterize genomic safe harbor sites (AAVS1, ROSA26, hROSA26) for stable transgene expression using CRISPR-engineered cell models.
What is Safe Harbor Loci ?
Safe harbor loci are genomic regions where transgenes can be integrated and expressed reliably without disrupting endogenous gene function. Commonly used sites include human AAVS1 and mouse ROSA26. CRISPR enables efficient targeting of these loci for generation of isogenic cell lines with consistent transgene expression for disease modeling and drug screening.
Key Research Applications
AAVS1/ROSA26 targeting efficiency validation
Stable transgene expression line generation
Inducible expression system integration
Reporter cell line construction
Isogenic disease model development
Products
Featured/Popular Targets
ALL
CCR5
CXCR4
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CXCR4 Knockout HEK293 Cell Line | EDJ-KQ1608 | Human | 7852 | Details Get a Quote |
| CCR5 Knockout HEK293 Cell Line | EDC07536 | Human | 1234 | Details Get a Quote |
| CXCR4 Knockout U2OS Cell Line | EDJ-KQ18082 | Human | 7852 | Details Get a Quote |
| CXCR4 Knockout HeLa Cell Line | EDJ-KQ19944 | Human | 7852 | Details Get a Quote |
| CXCR4 Knockout A-549 Cell Line | EDJ-KQ26289 | Human | 7852 | Details Get a Quote |
| CXCR4 Knockout Jurkat Cell Line | EDJ-KZ171 | Human | 7852 | Details Get a Quote |
| CCR5 Knockout HeLa Cell Line | EDJ-KQ52933 | Human | 1234 | Details Get a Quote |
| CCR5 Knockout A-549 Cell Line | EDJ-KQ61401 | Human | 1234 | Details Get a Quote |
| CCR5 Knockout HCT 116 Cell Line | EDJ-KQ69895 | Human | 1234 | Details Get a Quote |
| CXCR4 Knockout HCT 116 Cell Line | EDJ-KQ71760 | Human | 7852 | Details Get a Quote |
| (PX459) V3-CXCR4-sgRNA1 -puro | EDV3129 | 7852 | Details Get a Quote | |
| (PX459) V3-CXCR4-sgRNA2 -puro | EDV3130 | 7852 | Details Get a Quote | |
| CXCR4 Knockout HEK293T Cell Line | EDC07548 | Human | 7852 | Details Get a Quote |
| CXCR4 Overexpression HEK293 Stable Cell Line | EDJ-GQ95 | Human | 7852 | Details Get a Quote |
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