Overview
Nucleotide Metabolism
Study purine and pyrimidine biosynthesis, salvage pathways and their roles in cell proliferation, cancer and immune function using CRISPR-engineered cell models.
What is Nucleotide Metabolism ?
Nucleotide metabolism provides the building blocks for DNA and RNA synthesis through de novo and salvage pathways. Rapidly dividing cancer and immune cells heavily rely on de novo nucleotide synthesis. Enzymes in this pathway (e.g., DHODH, IMPDH) are established therapeutic targets for cancer, autoimmune disease and antiviral therapy.
Key Research Applications
De novo vs salvage pathway utilization assays
Antimetabolite drug screening
Nucleotide pool size and imbalance studies
Cancer cell proliferation dependency profiling
Immunosuppressive agent mechanism analysis
Products
Featured/Popular Targets
ALL
IMPDH2
HPRT1
PNP
SLC19A1
SLC29A1
SLC29A2
SLC29A4
DUS1L
DUS2
Product name Cat.No. Species Gene ID
PNP Knockout HEK293 Cell Line EDJ-KQ2248 Human 4860 Details Get a Quote
HPRT1 Knockout HEK293 Cell Line EDJ-KQ3913 Human 3251 Details Get a Quote
SLC29A2 Knockout HEK293 Cell Line EDJ-KQ4094 Human 3177 Details Get a Quote
SLC29A1 Knockout HEK293 Cell Line EDJ-KQ4531 Human 2030 Details Get a Quote
SLC19A1 Knockout HEK293 Cell Line EDC07995 Human 6573 Details Get a Quote
SLC29A4 Knockout HEK293 Cell Line EDJ-KQ9136 Human 222962 Details Get a Quote
DUS1L Knockout HEK293 Cell Line EDJ-KQ13221 Human 64118 Details Get a Quote
DUS2 Knockout HEK293 Cell Line EDJ-KQ13222 Human 54920 Details Get a Quote
HPRT1 Knockout A-549 Cell Line EDJ-KQ26134 Human 3251 Details Get a Quote
HPRT1 Knockout HCT 116 Cell Line EDJ-KQ26135 Human 3251 Details Get a Quote
HPRT1 Knockout HeLa Cell Line EDC90498 Human 3251 Details Get a Quote
SLC29A1 Knockout A-549 Cell Line EDJ-KQ27147 Human 2030 Details Get a Quote
SLC29A1 Knockout HCT 116 Cell Line EDC08625 Human 2030 Details Get a Quote
SLC29A1 Knockout HeLa Cell Line EDJ-KQ27149 Human 2030 Details Get a Quote
SLC19A1 Knockout A-549 Cell Line EDJ-KQ27948 Human 6573 Details Get a Quote
Displaying Records 1 To 15 Of 39 Records
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