ZYG11B
ZYG-11 Family Member B, Cell Cycle Regulator
Gene Information Card
| Symbol | ZYG11B |
|---|---|
| Full Name | ZYG-11 family member B |
| Gene Type | protein-coding |
| Chromosomal Location | 1p32.3 |
| NCBI Gene ID | 79699 ncbi.nlm.nih.gov/gene/79699 |
| Ensembl ID | ENSG00000162521 |
| UniProt ID | Q9C0B1 |
| OMIM ID | 617624 |
| HGNC ID | 26019 |
| Aliases | ZYG11, FLJ10858, MGC138290 |
Description
ZYG11B encodes a member of the ZYG-11 family, which is involved in cell cycle regulation and ubiquitin-dependent proteolysis. The protein is a substrate receptor for the cullin-RING E3 ubiquitin ligase complex, targeting specific proteins for degradation. It plays a role in mitotic progression and is implicated in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Overexpression may promote cell proliferation via altered ubiquitination | PubMed: 23455478 |
| Colorectal cancer | Upregulation associated with poor prognosis | PubMed: 29367642 |
| Breast cancer | Potential oncogenic role through cell cycle dysregulation | PubMed: 30150678 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Lymph node | 10.5 | Medium |
| Brain | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 12.0 | High expression |
| HeLa | 9.5 | Moderate expression |
| MCF7 | 7.8 | Moderate expression |
| A549 | 6.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | <0.01% | Unknown functional impact |
| c.567_569del (p.Lys189del) | In-frame deletion | <0.01% | Potential loss of function |
Mutation functional classification
Loss of Function (LOF)
Rare deletions or nonsense mutations may impair substrate recognition.
Gain of Function (GOF)
Not well characterized; overexpression in tumors suggests possible gain-of-function.
Dominant Negative (DN)
No evidence currently available.
View complete mutation data：
Gene Ontology (GO)
| • ubiquitin-protein transferase activity | • cell cycle |
| • protein ubiquitination | • nucleus |
| • cytoplasm |
Pathways
• Cullin-RING ubiquitin ligase complex
• Cell cycle
Protein Summary
ZYG11B is a 746-amino acid protein that functions as a substrate receptor for the CUL2-RING ubiquitin ligase complex. It contains a leucine-rich repeat (LRR) domain and a ZYG-11 homology domain. The protein is involved in targeting cell cycle regulators for proteasomal degradation, thereby controlling mitotic progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZYG11B Knockout HEK293 Cell Line | EDJ-KQ581 | Human | 79699 | Details Get a Quote |
| ZYG11B Knockout A-549 Cell Line | EDJ-KQ20339 | Human | 79699 | Details Get a Quote |
| ZYG11B Knockout HCT 116 Cell Line | EDJ-KQ20341 | Human | 79699 | Details Get a Quote |
| ZYG11B Knockout HeLa Cell Line | EDJ-KQ20342 | Human | 79699 | Details Get a Quote |
