ZSCAN21: Zinc Finger and SCAN Domain Containing 21
Transcriptional regulator with roles in development and potential implications in cancer
Gene Information Card
| Symbol | ZSCAN21 |
|---|---|
| Full Name | Zinc Finger and SCAN Domain Containing 21 |
| Gene Type | Protein coding |
| Chromosomal Location | 7q22.1 |
| NCBI Gene ID | 7589 ncbi.nlm.nih.gov/gene/7589 |
| Ensembl ID | ENSG00000105974 |
| UniProt ID | Q9Y2W1 |
| OMIM ID | 604262 |
| HGNC ID | 13096 |
| Aliases | ZNF38, ZSCAN21, NY-REN-45 |
Description
ZSCAN21 (Zinc Finger and SCAN Domain Containing 21) is a protein-coding gene that encodes a transcription factor belonging to the Krüppel C2H2-type zinc finger protein family. The protein contains a SCAN domain, which mediates homo- and hetero-oligomerization, and multiple C2H2 zinc finger motifs that facilitate DNA binding. ZSCAN21 is involved in the regulation of gene expression during development and cellular differentiation. It has been implicated in various cancers, including renal cell carcinoma, where it was identified as a tumor antigen (NY-REN-45).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Renal cell carcinoma | Overexpression as tumor antigen; potential role in immune recognition | PMID: 10508479 |
| Prostate cancer | Differential expression; possible involvement in tumor progression | PMID: 15674326 |
| Breast cancer | Altered expression levels; potential biomarker | PMID: 21799853 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Kidney | 8.7 | Low |
| Prostate | 6.5 | Low |
| Breast | 4.2 | Low |
| Brain | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.4 | Embryonic kidney cells |
| HeLa | 9.8 | Cervical cancer cells |
| MCF7 | 7.2 | Breast cancer cells |
| LNCaP | 6.1 | Prostate cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1012C>T (p.Arg338Trp) | Missense | 0.01% (gnomAD) | Unknown functional effect |
| c.1456G>A (p.Gly486Ser) | Missense | 0.005% (gnomAD) | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Gene expression (Transcription) - Reactome R-HSA-74160
• Developmental Biology - Reactome R-HSA-1266738
Protein Summary
ZSCAN21 is a 539-amino acid protein with a molecular weight of approximately 60 kDa. It contains an N-terminal SCAN domain (residues 1-80) and four C2H2-type zinc finger motifs (residues 200-400). The SCAN domain mediates protein-protein interactions, while the zinc fingers bind specific DNA sequences to regulate transcription. The protein is predominantly nuclear and is expressed in multiple tissues, with highest levels in testis and kidney. ZSCAN21 has been implicated in cellular differentiation and cancer, particularly renal cell carcinoma.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZSCAN21 Knockout HEK293 Cell Line | EDJ-KQ6046 | Human | 7589 | Details Get a Quote |
| ZSCAN21 Knockout A-549 Cell Line | EDJ-KQ29704 | Human | 7589 | Details Get a Quote |
| ZSCAN21 Knockout HCT 116 Cell Line | EDJ-KQ29705 | Human | 7589 | Details Get a Quote |
| ZSCAN21 Knockout HeLa Cell Line | EDJ-KQ29706 | Human | 7589 | Details Get a Quote |
