ZNF736
Zinc Finger Protein 736: A KRAB-ZNF Transcriptional Regulator
Gene Information Card
| Symbol | ZNF736 |
|---|---|
| Full Name | zinc finger protein 736 |
| Gene Type | protein-coding |
| Chromosomal Location | 7q11.21 |
| NCBI Gene ID | 100129924 ncbi.nlm.nih.gov/gene/100129924 |
| Ensembl ID | ENSG00000197977 |
| UniProt ID | A6NJT8 |
| OMIM ID | 618409 |
| HGNC ID | 33876 |
| Aliases | FLJ39660, MGC16384 |
Description
ZNF736 is a protein-coding gene that encodes a zinc finger protein of the Krüppel-associated box (KRAB) domain-containing family. KRAB-ZNF proteins typically function as transcriptional repressors by recruiting chromatin-modifying complexes. ZNF736 is located on chromosome 7q11.21 and is expressed in various tissues, with potential roles in development and disease.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not established | No direct evidence from curated databases |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.3 | Low |
| Lung | 6.1 | Low |
| Liver | 4.2 | Low |
| Kidney | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | Moderate expression |
| HeLa | 10.5 | Low expression |
| K562 | 8.9 | Low expression |
| HepG2 | 7.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No loss-of-function variants documented in curated databases.
Gain of Function (GOF)
No gain-of-function variants documented in curated databases.
Dominant Negative (DN)
No dominant-negative variants documented in curated databases.
View complete mutation data：
Gene Ontology (GO)
| • nucleic acid binding (GO:0003676) | • zinc ion binding (GO:0008270) |
| • nucleus (GO:0005634) | • metal ion binding (GO:0046872) |
Protein Summary
ZNF736 is a KRAB domain-containing zinc finger protein predicted to localize to the nucleus and bind nucleic acids. It likely functions as a transcriptional repressor through recruitment of chromatin modifiers, though its specific targets and biological roles remain largely uncharacterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF736 Knockout HEK293 Cell Line | EDJ-KQ16351 | Human | 728927 | Details Get a Quote |
| ZNF736 Knockout HeLa Cell Line | EDJ-KQ49949 | Human | 728927 | Details Get a Quote |
| ZNF736 Knockout A-549 Cell Line | EDJ-KQ69196 | Human | 728927 | Details Get a Quote |
| ZNF736 Knockout HCT 116 Cell Line | EDJ-KQ77553 | Human | 728927 | Details Get a Quote |
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