ZNF658 Gene: Function, Expression, and Disease Associations | Biomedical SEO

ZNF658 encodes a zinc finger protein belonging to the Krüppel-associated box (KRAB) domain-containing family of transcription factors. KRAB-ZFPs typically function as transcriptional repressors by recruiting chromatin-modifying complexes to specific genomic loci. ZNF658 contains multiple C2H2-type zinc finger domains, which mediate sequence-specific DNA binding. While its precise biological role is still under investigation, ZNF658 is expressed in various tissues and may be involved in regulating gene expression during development and cellular differentiation. The gene is located on chromosome 9p13.3, a region associated with several genetic disorders, suggesting potential clinical relevance.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• No specific pathways are curated for ZNF658 in major pathway databases (e.g.

• KEGG

• Reactome). As a KRAB-ZFP

• it may participate in chromatin remodeling and transcriptional repression pathways.

ZNF658 is a 658-amino acid protein containing an N-terminal KRAB domain and multiple C2H2 zinc finger motifs. The KRAB domain is known to mediate protein-protein interactions with co-repressors such as KAP1 (TRIM28), leading to histone methylation and transcriptional silencing. The zinc finger array likely recognizes specific DNA sequences, targeting the protein to particular gene promoters or enhancers. Structural predictions suggest a canonical C2H2 zinc finger fold, but experimental characterization of its DNA-binding specificity and target genes remains incomplete. ZNF658 is localized to the nucleus, consistent with its role as a transcription factor.