ZNF568: Zinc Finger Protein 568
A KRAB-ZFP transcription factor with potential roles in gene regulation and development
Gene Information Card
| Symbol | ZNF568 |
|---|---|
| Full Name | zinc finger protein 568 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.43 |
| NCBI Gene ID | 374900 ncbi.nlm.nih.gov/gene/374900 |
| Ensembl ID | ENSG00000188452 |
| UniProt ID | Q8N6T3 |
| OMIM ID | 619538 |
| HGNC ID | 26410 |
| Aliases | FLJ32709, MGC138499 |
Description
ZNF568 encodes a zinc finger protein of the Krüppel-associated box (KRAB) subfamily. KRAB-ZFPs are transcriptional repressors that recruit chromatin-modifying complexes to regulate gene expression during development and cellular differentiation. ZNF568 is located on chromosome 19q13.43 and is expressed in multiple tissues, with highest levels in testis and brain.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Thyroid | 6.1 | Low |
| Lung | 4.3 | Low |
| Liver | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 5.0 | Low expression |
| K562 | 3.2 | Low expression |
| HeLa | 2.8 | Low expression |
| HepG2 | 1.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
Pathways
• No curated pathways in Reactome or KEGG
Protein Summary
ZNF568 is a 649-amino acid protein containing a KRAB domain at the N-terminus and multiple C2H2-type zinc finger motifs. It is predicted to localize to the nucleus and function as a sequence-specific DNA-binding transcription repressor. The protein is conserved in primates and rodents, suggesting a role in mammalian gene regulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF568 Knockout HEK293 Cell Line | EDJ-KQ16295 | Human | 374900 | Details Get a Quote |
| ZNF568 Knockout A-549 Cell Line | EDJ-KQ47670 | Human | 374900 | Details Get a Quote |
| ZNF568 Knockout HeLa Cell Line | EDJ-KQ59907 | Human | 374900 | Details Get a Quote |
| ZNF568 Knockout HCT 116 Cell Line | EDJ-KQ76745 | Human | 374900 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
