ZNF479 Gene: Zinc Finger Protein 479 – Function, Expression, and Clinical Relevance
A comprehensive biomedical overview of ZNF479, including genomic context, expression profiles, mutations, and functional annotations.
Gene Information Card
| Symbol | ZNF479 |
|---|---|
| Full Name | Zinc finger protein 479 |
| Gene Type | protein-coding |
| Chromosomal Location | 7p11.2 |
| NCBI Gene ID | 339229 ncbi.nlm.nih.gov/gene/339229 |
| Ensembl ID | ENSG00000164825 |
| UniProt ID | Q8N5Y2 |
| OMIM ID | Not available |
| HGNC ID | 20984 |
| Aliases | FLJ16287, MGC138499 |
Description
ZNF479 encodes a zinc finger protein belonging to the Krüppel-associated box (KRAB) domain-containing zinc finger family. These proteins are transcription factors that typically function as repressors via recruitment of corepressor complexes. ZNF479 is located on chromosome 7p11.2 and is expressed in various tissues, with potential roles in development and cellular differentiation. Its specific biological functions and disease associations are still under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No curated disease association found in OMIM or ClinVar as of current data. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | Not available | Not available |
| Placenta | Not available | Not available |
| Brain | Not available | Not available |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No cell line data | Not available | No expression data available in the provided sources. |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | Not available | Not available | No variants reported in ClinVar or COSMIC for ZNF479. |
Mutation functional classification
Loss of Function (LOF)
No evidence of loss-of-function mutations reported.
Gain of Function (GOF)
No evidence of gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity | • zinc ion binding |
| • regulation of transcription by RNA polymerase II | • nucleus |
Pathways
• No specific pathways curated for ZNF479 in the provided databases.
Protein Summary
ZNF479 is a KRAB domain-containing zinc finger protein. KRAB-ZNF proteins are the largest family of transcription factors in humans and typically mediate transcriptional repression by recruiting the KAP1 corepressor complex, which leads to histone methylation and chromatin condensation. ZNF479 likely plays a role in regulating gene expression during development, but its specific target genes and physiological functions remain to be fully characterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF479 Knockout HEK293 Cell Line | EDJ-KQ10661 | Human | 90827 | Details Get a Quote |
| ZNF479 Knockout HeLa Cell Line | EDJ-KQ57785 | Human | 90827 | Details Get a Quote |
| ZNF479 Knockout A-549 Cell Line | EDJ-KQ66282 | Human | 90827 | Details Get a Quote |
| ZNF479 Knockout HCT 116 Cell Line | EDJ-KQ74700 | Human | 90827 | Details Get a Quote |
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