ZNF440 Zinc Finger Protein 440
Transcriptional regulator with C2H2 zinc finger domains; limited functional characterization
Gene Information Card
| Symbol | ZNF440 |
|---|---|
| Full Name | zinc finger protein 440 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.43 |
| NCBI Gene ID | 284390 ncbi.nlm.nih.gov/gene/284390 |
| Ensembl ID | ENSG00000171223 |
| UniProt ID | Q8N8K2 |
| OMIM ID | 618840 |
| HGNC ID | 20822 |
| Aliases | FLJ32942, MGC138290 |
Description
ZNF440 encodes a C2H2-type zinc finger protein, a member of the Krüppel-associated box (KRAB) zinc finger family. These proteins typically function as transcriptional repressors by recruiting chromatin-modifying complexes. ZNF440 is located on chromosome 19q13.43 within a large cluster of zinc finger genes. Its specific biological roles and target genes remain incompletely characterized, but it is predicted to bind DNA and regulate gene expression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No established disease association | Not determined | No curated evidence in OMIM, ClinVar, or COSMIC as of current data |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Thyroid | 8.2 | Low |
| Adrenal gland | 6.1 | Low |
| Brain (cerebellum) | 5.4 | Low |
| Lung | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.3 | Moderate expression |
| K562 | 9.7 | Low expression |
| HeLa | 7.2 | Low expression |
| HepG2 | 6.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1012C>T (p.Arg338Trp) | Missense | <0.01% (gnomAD) | Unknown functional impact |
| c.1456G>A (p.Gly486Ser) | Missense | <0.01% (gnomAD) | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in curated databases.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Not assigned to any curated pathway in Reactome or KEGG
Protein Summary
ZNF440 is a 636-amino acid protein containing multiple C2H2-type zinc finger domains and a KRAB domain at the N-terminus. The KRAB domain mediates interaction with KAP1/TRIM28, leading to transcriptional repression via histone modification. The zinc finger array is predicted to recognize specific DNA sequences. No 3D structure has been experimentally determined. Expression is highest in testis, suggesting a possible role in spermatogenesis or germ cell regulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF440 Knockout HuH-7 Cell Line | EDC90315 | Human | 126070 | Details Get a Quote |
| ZNF440 Knockout A-549 Cell Line | EDJ-KQ66653 | Human | 126070 | Details Get a Quote |
| ZNF440 Knockout HeLa Cell Line | EDJ-KQ35177 | Human | 126070 | Details Get a Quote |
| ZNF440 Knockout HCT 116 Cell Line | EDJ-KQ35176 | Human | 126070 | Details Get a Quote |
| ZNF440 Knockout HEK293 Cell Line | EDJ-KQ8856 | Human | 126070 | Details Get a Quote |
