ZNF385A: Zinc Finger Protein 385A
A zinc finger transcription factor implicated in cell cycle regulation and cancer
Gene Information Card
| Symbol | ZNF385A |
|---|---|
| Full Name | zinc finger protein 385A |
| Gene Type | protein-coding |
| Chromosomal Location | 12q13.13 |
| NCBI Gene ID | 25946 ncbi.nlm.nih.gov/gene/25946 |
| Ensembl ID | ENSG00000135446 |
| UniProt ID | Q96K83 |
| OMIM ID | 612300 |
| HGNC ID | 17525 |
| Aliases | HZF, ZNF385, ZNF385A |
Description
ZNF385A (zinc finger protein 385A) is a protein-coding gene located on chromosome 12q13.13. It encodes a zinc finger transcription factor involved in cell cycle regulation, particularly in the p53-dependent DNA damage response. The protein contains a C2H2-type zinc finger domain and is implicated in transcriptional repression. ZNF385A has been associated with various cancers, including breast, lung, and colorectal cancer, where it may act as a tumor suppressor or oncogene depending on context.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered expression of ZNF385A may disrupt p53-mediated cell cycle arrest and apoptosis, promoting tumorigenesis. | PMID: 23455423 |
| Lung cancer | ZNF385A overexpression correlates with poor prognosis; may enhance proliferation via cell cycle dysregulation. | PMID: 25636847 |
| Colorectal cancer | ZNF385A downregulation is associated with advanced stage and metastasis; potential tumor suppressor role. | PMID: 27840973 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Lung | 8.7 | Low |
| Breast | 6.2 | Low |
| Colon | 5.1 | Low |
| Brain | 2.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung cancer) | 9.5 | High expression |
| MCF7 (breast cancer) | 7.8 | Moderate expression |
| HCT116 (colorectal cancer) | 4.2 | Low expression |
| HEK293 (embryonic kidney) | 3.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.437G>A (p.Arg146Gln) | Missense | <0.01% | Unknown functional impact; reported in COSMIC |
| c.1012C>T (p.Arg338Trp) | Missense | <0.01% | Located in zinc finger domain; may affect DNA binding |
| c.1543_1544insA | Frameshift | <0.01% | Predicted loss of function; truncation |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.1543_1544insA) are predicted to cause loss of function by truncating the protein.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity (GO:0003700) | • zinc ion binding (GO:0008270) |
| • DNA-templated (GO:0006355) | • cell cycle (GO:0007049) |
| • apoptotic process (GO:0006915) |
Pathways
• p53 signaling pathway (KEGG: hsa04115)
• Cell cycle (KEGG: hsa04110)
Protein Summary
ZNF385A encodes a 422-amino acid protein with a C2H2-type zinc finger domain. It localizes to the nucleus and functions as a transcription factor. The protein interacts with p53 and modulates its transcriptional activity, influencing cell cycle arrest and apoptosis. ZNF385A is expressed in multiple tissues, with highest levels in testis. Its dysregulation is linked to several cancers, suggesting a role in tumor suppression or oncogenesis depending on cellular context.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF385A Knockout HEK293 Cell Line | EDJ-KQ8317 | Human | 25946 | Details Get a Quote |
| ZNF385A Knockout A-549 Cell Line | EDJ-KQ32978 | Human | 25946 | Details Get a Quote |
| ZNF385A Knockout HCT 116 Cell Line | EDJ-KQ34303 | Human | 25946 | Details Get a Quote |
| ZNF385A Knockout HeLa Cell Line | EDJ-KQ34304 | Human | 25946 | Details Get a Quote |
