ZNF358 (Zinc Finger Protein 358)
Transcriptional regulator with potential roles in cellular differentiation and disease
Gene Information Card
| Symbol | ZNF358 |
|---|---|
| Full Name | zinc finger protein 358 |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.2 |
| NCBI Gene ID | 140467 ncbi.nlm.nih.gov/gene/140467 |
| Ensembl ID | ENSG00000167552 |
| UniProt ID | Q9H7N4 |
| OMIM ID | 611634 |
| HGNC ID | 15962 |
| Aliases | FLJ11184, ZNF358A |
Description
ZNF358 encodes a zinc finger protein of the Krüppel C2H2-type family, likely functioning as a transcription factor through sequence-specific DNA binding. The protein contains multiple C2H2 zinc finger domains and is predicted to localize to the nucleus. Its precise biological roles remain under investigation, but it may be involved in transcriptional regulation during development and cellular differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association established | Not determined | No curated evidence in OMIM, ClinVar, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 4.2 | Low |
| Thyroid | 3.1 | Low |
| Prostate | 2.8 | Low |
| Brain | 1.5 | Not detected |
| Liver | 0.9 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 3.5 | Low expression |
| HeLa | 2.1 | Low expression |
| K562 | 1.8 | Low expression |
| A549 | 1.2 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No loss-of-function mutations documented in ClinVar or COSMIC.
Gain of Function (GOF)
No gain-of-function mutations documented.
Dominant Negative (DN)
No dominant-negative mutations documented.
View complete mutation data：
Gene Ontology (GO)
| • nucleic acid binding (GO:0003676) | • zinc ion binding (GO:0008270) |
| • nucleus (GO:0005634) | • metal ion binding (GO:0046872) |
Protein Summary
ZNF358 is a 478-amino-acid protein containing 11 C2H2-type zinc finger domains. It is predicted to act as a DNA-binding transcription factor. The protein is expressed at low levels in a limited set of tissues and cell lines. No disease-associated variants or functional pathways have been experimentally validated.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF358 Knockout HEK293 Cell Line | EDJ-KQ9772 | Human | 140467 | Details Get a Quote |
| ZNF358 Knockout HCT 116 Cell Line | EDJ-KQ35401 | Human | 140467 | Details Get a Quote |
| ZNF358 Knockout A-549 Cell Line | EDJ-KQ36615 | Human | 140467 | Details Get a Quote |
| ZNF358 Knockout HeLa Cell Line | EDJ-KQ36616 | Human | 140467 | Details Get a Quote |
