ZNF326: A Zinc Finger Protein with Emerging Roles in Transcriptional Regulation and Cancer
Comprehensive biomedical overview of ZNF326, including gene characteristics, expression, mutations, and disease associations.
Gene Information Card
| Symbol | ZNF326 |
|---|---|
| Full Name | Zinc finger protein 326 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p22.3 |
| NCBI Gene ID | 284695 ncbi.nlm.nih.gov/gene/284695 |
| Ensembl ID | ENSG00000162676 |
| UniProt ID | Q5BKZ1 |
| OMIM ID | 614828 |
| HGNC ID | 24841 |
| Aliases | DBP, ZNF326, zinc finger protein 326 |
Description
ZNF326 (zinc finger protein 326) is a protein-coding gene located on chromosome 1p22.3. It encodes a zinc finger protein that likely functions as a transcription factor, involved in RNA polymerase II-mediated transcription. The protein contains multiple C2H2-type zinc finger domains and may play a role in cellular differentiation and development. ZNF326 has been implicated in various cancers, including breast cancer and glioblastoma, where its expression is dysregulated.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered expression of ZNF326 may influence tumor progression through transcriptional regulation of target genes. | NCBI Gene, PubMed |
| Glioblastoma | ZNF326 expression is upregulated in glioblastoma and may contribute to cell proliferation. | NCBI Gene, PubMed |
| Colorectal cancer | ZNF326 overexpression associated with poor prognosis and metastasis. | COSMIC, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Low |
| Breast | 8.1 | Medium |
| Colon | 6.7 | Medium |
| Lung | 4.3 | Low |
| Liver | 3.9 | Low |
| Testis | 12.5 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 9.8 | Moderate expression |
| U87MG (glioblastoma) | 11.2 | High expression |
| HCT116 (colorectal cancer) | 7.5 | Moderate expression |
| HEK293 (embryonic kidney) | 6.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1000G>A (p.Gly334Arg) | Missense | <0.1% | Unknown functional impact; reported in COSMIC |
| c.1456C>T (p.Arg486*) | Nonsense | <0.1% | Predicted loss of function; truncation |
| c.789_790insA | Frameshift insertion | <0.1% | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations (e.g., p.Arg486*, c.789_790insA) are predicted to cause loss of function by truncating the protein or disrupting zinc finger domains.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported for ZNF326.
Dominant Negative (DN)
No evidence for dominant-negative effects currently available.
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity (GO:0003700) | • Zinc ion binding (GO:0008270) |
| • Nucleus (GO:0005634) | • Regulation of transcription by RNA polymerase II (GO:0006357) |
Pathways
• RNA polymerase II transcription
• Transcriptional misregulation in cancer (KEGG hsa05202)
Protein Summary
ZNF326 encodes a 582-amino acid protein containing multiple C2H2-type zinc finger domains, characteristic of transcription factors. The protein localizes to the nucleus and is involved in RNA polymerase II-mediated transcription. It may interact with other transcriptional regulators to modulate gene expression. Expression data suggest a role in brain, breast, and colorectal tissues, with dysregulation observed in several cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF326 Knockout HEK293 Cell Line | EDJ-KQ7481 | Human | 284695 | Details Get a Quote |
| ZNF326 Knockout A-549 Cell Line | EDJ-KQ32709 | Human | 284695 | Details Get a Quote |
| ZNF326 Knockout HCT 116 Cell Line | EDJ-KQ32710 | Human | 284695 | Details Get a Quote |
| ZNF326 Knockout HeLa Cell Line | EDJ-KQ32711 | Human | 284695 | Details Get a Quote |
