ZNF267: Zinc Finger Protein 267
Transcriptional Regulator and Potential Oncogene
Gene Information Card
| Symbol | ZNF267 |
|---|---|
| Full Name | Zinc Finger Protein 267 |
| Gene Type | Protein coding |
| Chromosomal Location | 16p11.2 |
| NCBI Gene ID | 10308 ncbi.nlm.nih.gov/gene/10308 |
| Ensembl ID | ENSG00000140987 |
| UniProt ID | Q14586 |
| OMIM ID | 604752 |
| HGNC ID | 13095 |
| Aliases | HZF2, ZNF267A, ZNF267B |
Description
ZNF267 (Zinc Finger Protein 267) is a protein-coding gene located on chromosome 16p11.2. It encodes a member of the Krüppel-associated box (KRAB) zinc finger protein family, which functions as a transcriptional repressor. ZNF267 is involved in DNA binding and regulation of gene expression, with emerging roles in cellular proliferation and cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular Carcinoma | Overexpression of ZNF267 promotes cell proliferation and migration via transcriptional regulation of target genes. | PMID: 25605248 |
| Gastric Cancer | Upregulation of ZNF267 correlates with poor prognosis and may enhance tumor growth. | PMID: 29351287 |
| Colorectal Cancer | ZNF267 expression is elevated in tumor tissues and associated with metastasis. | PMID: 30323267 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 4.2 | Low |
| Testis | 3.8 | Low |
| Bone Marrow | 2.1 | Not detected |
| Lung | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 5.1 | Hepatocellular carcinoma cell line |
| MCF7 | 3.4 | Breast cancer cell line |
| HeLa | 2.8 | Cervical cancer cell line |
| A549 | 1.9 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.112C>T | Missense | <0.1% | p.Arg38Cys; potential loss of DNA binding |
| c.245G>A | Missense | <0.1% | p.Arg82His; unknown significance |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants may impair zinc finger domain integrity and DNA binding.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • DNA binding | • zinc ion binding |
| • transcription cis-regulatory region binding | • negative regulation of transcription by RNA polymerase II |
| • nucleus |
Pathways
• KRAB-ZNF transcriptional repression
• Gene expression (Transcription)
Protein Summary
ZNF267 is a KRAB zinc finger protein of 648 amino acids. It contains an N-terminal KRAB domain responsible for transcriptional repression and multiple C2H2 zinc finger motifs that mediate sequence-specific DNA binding. The protein localizes to the nucleus and is thought to regulate genes involved in cell growth and differentiation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF267 Knockout HEK293 Cell Line | EDJ-KQ6998 | Human | 10308 | Details Get a Quote |
| ZNF267 Knockout HCT 116 Cell Line | EDJ-KQ30348 | Human | 10308 | Details Get a Quote |
| ZNF267 Knockout A-549 Cell Line | EDJ-KQ31729 | Human | 10308 | Details Get a Quote |
| ZNF267 Knockout HeLa Cell Line | EDJ-KQ31730 | Human | 10308 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
