ZNF266: Zinc Finger Protein 266 - A KRAB-ZNF Transcriptional Regulator
Comprehensive genomic and functional analysis of ZNF266, a Krüppel-associated box zinc finger protein with roles in transcriptional repression and potential links to cancer and developmental disorders.
Gene Information Card
| Symbol | ZNF266 |
|---|---|
| Full Name | zinc finger protein 266 |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.2 |
| NCBI Gene ID | 10781 ncbi.nlm.nih.gov/gene/10781 |
| Ensembl ID | ENSG00000160193 |
| UniProt ID | Q14584 |
| OMIM ID | 604752 |
| HGNC ID | 13072 |
| Aliases | ZNF266A, ZNF266B, HZF1, ZKSCAN19 |
Description
ZNF266 (zinc finger protein 266) is a protein-coding gene located on chromosome 19p13.2. It belongs to the Krüppel-associated box (KRAB) zinc finger protein family, which functions primarily as transcriptional repressors. The encoded protein contains an N-terminal KRAB domain and multiple C2H2-type zinc finger motifs, enabling sequence-specific DNA binding and recruitment of co-repressor complexes such as KAP1/TRIM28. ZNF266 is involved in regulating gene expression during development and cellular differentiation, and its dysregulation has been implicated in various cancers and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | ZNF266 overexpression may promote tumor growth via transcriptional repression of tumor suppressor genes; altered expression observed in breast cancer cell lines and tissues. | COSMIC; NCBI Gene; PubMed (limited evidence) |
| Colorectal cancer | ZNF266 expression changes correlate with poor prognosis; potential role in Wnt/β-catenin pathway modulation. | COSMIC; NCBI Gene; PubMed (limited evidence) |
| Developmental disorders | Rare variants in ZNF266 have been reported in patients with intellectual disability and congenital anomalies, suggesting a role in neurodevelopment. | ClinVar; OMIM (604752) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain (cerebral cortex) | 8.2 | Low |
| Lung | 6.7 | Low |
| Liver | 4.3 | Low |
| Kidney | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.1 | Embryonic kidney; moderate expression |
| HeLa | 7.8 | Cervical carcinoma; low expression |
| MCF7 | 9.4 | Breast cancer; moderate expression |
| HepG2 | 6.2 | Hepatocellular carcinoma; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1012C>T (p.Arg338Trp) | Missense | <0.01% | Alters zinc finger domain; potential loss of DNA binding |
| c.1456G>A (p.Gly486Ser) | Missense | <0.01% | Located in linker region; functional impact unknown |
| c.1789_1791del (p.Lys597del) | In-frame deletion | <0.01% | Deletion in C-terminal region; may affect protein stability |
Mutation functional classification
Loss of Function (LOF)
Missense mutations in zinc finger domains (e.g., p.Arg338Trp) likely impair DNA binding and transcriptional repression.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported; overexpression in cancer may represent a non-mutational gain.
Dominant Negative (DN)
No evidence for dominant-negative effects; potential if mutant protein interferes with wild-type ZNF266 or co-repressor complexes.
View complete mutation data：
Gene Ontology (GO)
Pathways
• KAP1/TRIM28-mediated transcriptional repression
• KRAB-ZNF signaling pathway
Protein Summary
ZNF266 encodes a 647-amino acid protein with a KRAB domain at the N-terminus and 14 C2H2-type zinc finger motifs. The KRAB domain mediates interaction with KAP1/TRIM28, recruiting histone modifiers (e.g., SETDB1, HDACs) to silence target genes. The zinc fingers confer sequence-specific DNA binding, typically to GC-rich promoters. ZNF266 is predominantly nuclear and acts as a transcriptional repressor, with roles in cell cycle control, differentiation, and development. Post-translational modifications include phosphorylation and SUMOylation, which modulate its activity and stability.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF266 Knockout HEK293 Cell Line | EDJ-KQ7163 | Human | 10781 | Details Get a Quote |
| ZNF266 Knockout HCT 116 Cell Line | EDJ-KQ32077 | Human | 10781 | Details Get a Quote |
| ZNF266 Knockout HeLa Cell Line | EDJ-KQ32078 | Human | 10781 | Details Get a Quote |
| ZNF266 Knockout A-549 Cell Line | EDJ-KQ30698 | Human | 10781 | Details Get a Quote |
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