ZNF263: Zinc Finger Protein 263
A C2H2-type zinc finger transcription factor involved in transcriptional regulation and potential tumor suppression.
Gene Information Card
| Symbol | ZNF263 |
|---|---|
| Full Name | Zinc Finger Protein 263 |
| Gene Type | Protein coding |
| Chromosomal Location | 16p11.2 |
| NCBI Gene ID | 10127 ncbi.nlm.nih.gov/gene/10127 |
| Ensembl ID | ENSG00000140987 |
| UniProt ID | O14978 |
| OMIM ID | 604191 |
| HGNC ID | 13059 |
| Aliases | FPM315, ZKSCAN12, ZNF306, ZSCAN44 |
Description
ZNF263 is a C2H2-type zinc finger protein that functions as a transcription factor. It contains a KRAB domain and a SCAN domain, and is involved in transcriptional repression and regulation of cell proliferation. The gene is located on chromosome 16p11.2 and is expressed in multiple tissues. Alterations in ZNF263 have been implicated in cancer and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Potential tumor suppressor; loss of expression may promote proliferation | COSMIC; PMID: 25691885 |
| Colorectal cancer | Downregulation associated with poor prognosis | COSMIC; PMID: 27149991 |
| Intellectual disability | De novo missense variants reported in neurodevelopmental disorders | ClinVar; PMID: 28135719 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.3 | Low |
| Lung | 6.1 | Low |
| Liver | 4.7 | Low |
| Kidney | 5.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.2 | Embryonic kidney |
| HeLa | 7.8 | Cervical carcinoma |
| MCF7 | 6.5 | Breast cancer |
| A549 | 5.3 | Lung cancer |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1012C>T (p.Arg338Trp) | Missense | <0.01% | Unknown; reported in ClinVar |
| c.1456G>A (p.Glu486Lys) | Missense | <0.01% | Unknown; reported in ClinVar |
| c.1687C>T (p.Arg563*) | Nonsense | <0.01% | Loss of function; predicted truncation |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., p.Arg563*) likely lead to loss of transcriptional repression activity.
Gain of Function (GOF)
No evidence for gain-of-function mutations in ZNF263.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Not assigned to any specific KEGG or Reactome pathway.
Protein Summary
ZNF263 encodes a 684-amino acid protein containing a KRAB domain, a SCAN domain, and 11 C2H2-type zinc finger motifs. It localizes to the nucleus and acts as a transcriptional repressor. The protein is expressed in various tissues and may play a role in cell cycle regulation and tumor suppression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF263 Knockout HEK293 Cell Line | EDJ-KQ6906 | Human | 10127 | Details Get a Quote |
| ZNF263 Knockout A-549 Cell Line | EDJ-KQ30159 | Human | 10127 | Details Get a Quote |
| ZNF263 Knockout HCT 116 Cell Line | EDJ-KQ31534 | Human | 10127 | Details Get a Quote |
| ZNF263 Knockout HeLa Cell Line | EDJ-KQ31535 | Human | 10127 | Details Get a Quote |
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