ZNF260: Zinc Finger Protein 260
Transcriptional Regulator with Emerging Roles in Development and Disease
Gene Information Card
| Symbol | ZNF260 |
|---|---|
| Full Name | zinc finger protein 260 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.43 |
| NCBI Gene ID | 339324 ncbi.nlm.nih.gov/gene/339324 |
| Ensembl ID | ENSG00000167552 |
| UniProt ID | Q9H6J7 |
| OMIM ID | 618544 |
| HGNC ID | 13063 |
| Aliases | FLJ20184, MGC138499, MGC138501 |
Description
ZNF260 encodes a zinc finger protein of the Krüppel-associated box (KRAB) subfamily. The protein contains a KRAB domain at the N-terminus and multiple C2H2-type zinc finger motifs, suggesting a role in transcriptional regulation through DNA binding and chromatin remodeling. ZNF260 is expressed in various tissues and may be involved in developmental processes and cellular differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.1 | Embryonic kidney cell line |
| K562 | 7.8 | Leukemia cell line |
| HeLa | 6.5 | Cervical cancer cell line |
| HepG2 | 5.2 | Hepatocellular carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
Protein Summary
ZNF260 is a 584-amino acid protein with a KRAB domain (residues 1-75) and 13 C2H2-type zinc finger domains (residues 140-560). It localizes to the nucleus and is predicted to bind specific DNA sequences to regulate transcription. The KRAB domain mediates interaction with KAP1/TRIM28, recruiting chromatin-modifying complexes for transcriptional repression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF260 Knockout HEK293 Cell Line | EDJ-KQ3447 | Human | 339324 | Details Get a Quote |
| ZNF260 Knockout A-549 Cell Line | EDJ-KQ25183 | Human | 339324 | Details Get a Quote |
| ZNF260 Knockout HeLa Cell Line | EDJ-KQ25184 | Human | 339324 | Details Get a Quote |
| ZNF260 Knockout HCT 116 Cell Line | EDJ-KQ76480 | Human | 339324 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
