ZNF26: Zinc Finger Protein 26 – Gene Overview and Clinical Significance
Comprehensive biomedical resource for ZNF26, including genomic annotation, expression, mutations, and disease associations.
Gene Information Card
| Symbol | ZNF26 |
|---|---|
| Full Name | zinc finger protein 26 |
| Gene Type | protein-coding |
| Chromosomal Location | 12q13.13 |
| NCBI Gene ID | 7574 ncbi.nlm.nih.gov/gene/7574 |
| Ensembl ID | ENSG00000135446 |
| UniProt ID | P17031 |
| OMIM ID | 194538 |
| HGNC ID | 13094 |
| Aliases | ZNF26, Zfp26, FLJ32130 |
Description
ZNF26 (zinc finger protein 26) is a protein-coding gene located on chromosome 12q13.13. It encodes a member of the Krüppel C2H2-type zinc finger protein family, which typically functions as transcription factors. ZNF26 is involved in transcriptional regulation and may play roles in cell differentiation and development. Expression data indicate broad tissue distribution, and alterations have been reported in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered expression and copy number variations; potential oncogenic or tumor suppressor role | COSMIC; ClinVar |
| Breast cancer | Overexpression observed in some studies; functional role unclear | COSMIC |
| Lung cancer | Somatic mutations and expression changes reported | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.3 | Low |
| Lung | 6.1 | Low |
| Liver | 4.7 | Low |
| Kidney | 5.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 9.2 | Embryonic kidney; moderate expression |
| HeLa | 7.8 | Cervical cancer; moderate expression |
| A549 | 6.5 | Lung cancer; low expression |
| MCF7 | 8.1 | Breast cancer; moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1000C>T | missense | 0.02% | p.Arg334Cys; uncertain significance |
| c.1456G>A | missense | 0.01% | p.Gly486Ser; uncertain significance |
| c.789_790insA | frameshift | <0.01% | Loss of function; rare |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense variants predicted to cause loss of function; rare in population databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity (GO:0003700) | • zinc ion binding (GO:0008270) |
| • nucleus (GO:0005634) | • DNA-templated (GO:0006355) |
Pathways
• No specific curated pathways; predicted involvement in transcriptional regulation.
Protein Summary
ZNF26 encodes a 532-amino acid protein containing multiple C2H2-type zinc finger domains, characteristic of transcription factors. The protein localizes to the nucleus and binds DNA to regulate gene expression. Its precise biological functions remain under investigation, but it is broadly expressed and may contribute to cellular differentiation and cancer biology.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF260 Knockout HEK293 Cell Line | EDJ-KQ3447 | Human | 339324 | Details Get a Quote |
| ZNF26 Knockout HEK293 Cell Line | EDJ-KQ6040 | Human | 7574 | Details Get a Quote |
| ZNF264 Knockout HEK293 Cell Line | EDJ-KQ6588 | Human | 9422 | Details Get a Quote |
| ZNF263 Knockout HEK293 Cell Line | EDJ-KQ6906 | Human | 10127 | Details Get a Quote |
| ZNF267 Knockout HEK293 Cell Line | EDJ-KQ6998 | Human | 10308 | Details Get a Quote |
| ZNF266 Knockout HEK293 Cell Line | EDJ-KQ7163 | Human | 10781 | Details Get a Quote |
| ZNF260 Knockout A-549 Cell Line | EDJ-KQ25183 | Human | 339324 | Details Get a Quote |
| ZNF260 Knockout HeLa Cell Line | EDJ-KQ25184 | Human | 339324 | Details Get a Quote |
| ZNF263 Knockout A-549 Cell Line | EDJ-KQ30159 | Human | 10127 | Details Get a Quote |
| ZNF266 Knockout HCT 116 Cell Line | EDJ-KQ32077 | Human | 10781 | Details Get a Quote |
| ZNF266 Knockout HeLa Cell Line | EDJ-KQ32078 | Human | 10781 | Details Get a Quote |
| ZNF26 Knockout HeLa Cell Line | EDJ-KQ28400 | Human | 7574 | Details Get a Quote |
| ZNF264 Knockout HCT 116 Cell Line | EDJ-KQ29465 | Human | 9422 | Details Get a Quote |
| ZNF26 Knockout A-549 Cell Line | EDJ-KQ29686 | Human | 7574 | Details Get a Quote |
| ZNF26 Knockout HCT 116 Cell Line | EDJ-KQ29687 | Human | 7574 | Details Get a Quote |
Displaying Records 1 To 15 Of 28 Records
