ZNF256: Zinc Finger Protein 256
A KRAB-ZNF transcription factor with potential roles in gene regulation and disease
Gene Information Card
| Symbol | ZNF256 |
|---|---|
| Full Name | zinc finger protein 256 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.43 |
| NCBI Gene ID | 10172 ncbi.nlm.nih.gov/gene/10172 |
| Ensembl ID | ENSG00000105675 |
| UniProt ID | Q9Y2P5 |
| OMIM ID | None |
| HGNC ID | 13043 |
| Aliases | KIAA0386, ZNF256L |
Description
ZNF256 (zinc finger protein 256) is a protein-coding gene located on chromosome 19q13.43. It belongs to the Krüppel-associated box (KRAB) zinc finger protein family, which are transcriptional regulators involved in diverse processes such as development, differentiation, and apoptosis. The encoded protein contains multiple C2H2-type zinc finger domains and a KRAB domain, suggesting it functions as a transcription repressor. ZNF256 is expressed in various tissues and may play a role in cellular signaling and disease, though its specific functions are not fully characterized.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.0 | Moderate expression |
| HeLa | 10.2 | Moderate expression |
| K562 | 8.5 | Low expression |
| HepG2 | 6.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
Pathways
• No curated pathways
Protein Summary
ZNF256 encodes a 648-amino acid protein with a KRAB domain at the N-terminus and 12 C2H2-type zinc finger motifs. The KRAB domain mediates transcriptional repression through recruitment of co-repressors, while the zinc fingers facilitate sequence-specific DNA binding. The protein is localized to the nucleus and is predicted to regulate gene expression. Its exact biological roles remain under investigation, but it may be involved in cell differentiation and development.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF256 Knockout HEK293 Cell Line | EDJ-KQ6939 | Human | 10172 | Details Get a Quote |
| ZNF256 Knockout A-549 Cell Line | EDJ-KQ31594 | Human | 10172 | Details Get a Quote |
| ZNF256 Knockout HeLa Cell Line | EDJ-KQ55335 | Human | 10172 | Details Get a Quote |
| ZNF256 Knockout HCT 116 Cell Line | EDJ-KQ72277 | Human | 10172 | Details Get a Quote |
